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    znf-598 RING-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

    Gene ID: 174148, updated on 9-Dec-2024

    Summary

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    Official Symbol
    znf-598
    Official Full Name
    RING-type E3 ubiquitin transferase
    Primary source
    WormBase:WBGene00016888
    Locus tag
    CELE_C52E12.1
    See related
    AllianceGenome:WB:WBGene00016888
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ribosome binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and rescue of stalled ribosome. Predicted to be located in cytoplasm. Orthologous to human ZNF598 (zinc finger protein 598, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See znf-598 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    15
    Sequence:
    Chromosome: II; NC_003280.10 (7025802..7030156)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Lateral Signaling Target Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitination of stalled ribosomes enables mRNA decay via HBS-1 and NONU-1 in vivo. Monem PC, et al. PLoS Genet, 2023 Jan. PMID 36626369, Free PMC Article
    2. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
    3. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rescue of stalled ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rescue of stalled ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING-type E3 ubiquitin transferase
    NP_001362178.1
    • Confirmed by transcript evidence
    NP_495439.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7025802..7030156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001375249.1 → NP_001362178.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5K1ICF1
      Conserved Domains (2) summary
      COG5236
      Location:47 → 356
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00020
      Location:183 → 210
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_063038.6 → NP_495439.2  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495439.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18782
      Conserved Domains (2) summary
      COG5236
      Location:47 → 356
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00020
      Location:183 → 210
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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