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    ppm-1.D PPM-type phosphatase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190269, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ppm-1.D
    Official Full Name
    PPM-type phosphatase domain-containing protein
    Primary source
    WormBase:WBGene00021856
    Locus tag
    CELE_Y54F10BM.1
    See related
    AllianceGenome:WB:WBGene00021856
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mitogen-activated protein kinase binding activity and protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of gene expression, epigenetic and regulation of intracellular signal transduction. Is expressed in distal tip cell and germline blastomere. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See ppm-1.D in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (2331572..2343223)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Eukaryotic translation initiation factor 5B Neighboring gene Insulin/EGF-Receptor L Domain protein Neighboring gene Dual specificity protein phosphatase 19 Neighboring gene PHD finger-like domain-containing protein 5A Neighboring gene Gamma-tubulin complex component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Release of CHK-2 from PPM-1.D anchorage schedules meiotic entry. Baudrimont A, et al. Sci Adv, 2022 Feb 18. PMID 35171669, Free PMC Article
    2. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of gene expression, epigenetic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PPM-type phosphatase domain-containing protein
    NP_497539.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2331572..2343223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065138.5 → NP_497539.3  PPM-type phosphatase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497539.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95XK4
      Conserved Domains (1) summary
      cd00143
      Location:19 → 333
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein
    Heading Accession and Version

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