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    algn-5 Dolichyl-phosphate beta-glucosyltransferase;dolichyl-phosphate beta-glucosyltransferase [ Caenorhabditis elegans ]

    Gene ID: 178822, updated on 9-Dec-2024

    Summary

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    Official Symbol
    algn-5
    Official Full Name
    Dolichyl-phosphate beta-glucosyltransferase;dolichyl-phosphate beta-glucosyltransferase
    Primary source
    WormBase:WBGene00019276
    Locus tag
    CELE_H43I07.3
    See related
    AllianceGenome:WB:WBGene00019276
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dolichyl-phosphate beta-glucosyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in body wall musculature; nervous system; and pharynx. Human ortholog(s) of this gene implicated in polycystic kidney disease 7. Orthologous to human ALG5 (ALG5 dolichyl-phosphate beta-glucosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See algn-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (4195577..4199399)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Protein pid-5 Neighboring gene Aftiphilin clathrin-binding box domain-containing protein;Clathrin_bdg domain-containing protein;Transcription factor Neighboring gene Nuclear hormone receptor 114 Neighboring gene DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein Neighboring gene OPA3-like protein;Peroxin-14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article
    2. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dolichyl-phosphate beta-glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dolichyl-phosphate beta-glucosyltransferase;dolichyl-phosphate beta-glucosyltransferase
    NP_001317828.1
    • Confirmed by transcript evidence
    NP_741523.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4195577..4199399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171446.4 → NP_741523.1  dolichyl-phosphate beta-glucosyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741523.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WSL9
      Conserved Domains (1) summary
      cd04188
      Location:85 → 307
      DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation

    2. NM_001330840.3 → NP_001317828.1  Dolichyl-phosphate beta-glucosyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A168H9F5
      Conserved Domains (1) summary
      cl11394
      Location:1 → 145
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein
    Heading Accession and Version

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