hphd-1 Hydroxyacid-oxoacid transhydrogenase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hphd-1
Official Full Name: Hydroxyacid-oxoacid transhydrogenase, mitochondrial
Primary source: WormBase:WBGene00012608
Locus tag: CELE_Y38F1A.6
See related: AllianceGenome:WB:WBGene00012608
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable alcohol dehydrogenase (NAD+) activity and hydroxyacid-oxoacid transhydrogenase activity. Predicted to be involved in glutamate catabolic process via 2-hydroxyglutarate. Predicted to be active in mitochondrion. Is expressed in several structures, including anal depressor muscle; body wall musculature; intestine; pharynx; and reproductive system. Orthologous to human ADHFE1 (alcohol dehydrogenase iron containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hphd-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (12994362..12996344, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y38F1A.6 (e-PCR)
- UniSTS:317302

Y38F1A.7 (e-PCR)
- UniSTS:317303

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables alcohol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydroxyacid-oxoacid transhydrogenase activity	IEA Inferred from Electronic Annotation more info
enables hydroxyacid-oxoacid transhydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutamate catabolic process via 2-hydroxyglutarate	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Hydroxyacid-oxoacid transhydrogenase, mitochondrial

NP_496764.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

12994362..12996344 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064363.8 → NP_496764.1 Hydroxyacid-oxoacid transhydrogenase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496764.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U2M4

Conserved Domains (1) summary

cd08190
Location:48 → 462

HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism