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    F08F3.4 NAD-dependent epimerase/dehydratase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178924, updated on 2-Nov-2024

    Summary

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    Official Symbol
    F08F3.4
    Official Full Name
    NAD-dependent epimerase/dehydratase domain-containing protein
    Primary source
    WormBase:WBGene00017262
    Locus tag
    CELE_F08F3.4
    See related
    AllianceGenome:WB:WBGene00017262
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable L-threonine 3-dehydrogenase activity. Involved in innate immune response. Orthologous to human TDH (L-threonine dehydrogenase (pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See F08F3.4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (5410955..5413001)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Serine/threonine-protein phosphatase Neighboring gene Uncharacterized protein Neighboring gene F-box domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
    2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-threonine 3-dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    involved_in threonine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NAD-dependent epimerase/dehydratase domain-containing protein
    NP_504433.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5410955..5413001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072032.7 → NP_504433.2  NAD-dependent epimerase/dehydratase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504433.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22945
      Conserved Domains (1) summary
      cd05272
      Location:39 → 344
      TDH_SDR_e; L-threonine dehydrogenase, extended (e) SDRs
    Nucleotide Protein
    Heading Accession and Version

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