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    Aqr aquarius intron-binding spliceosomal factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366163, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aqrprovided by RGD
    Official Full Name
    aquarius intron-binding spliceosomal factorprovided by RGD
    Primary source
    RGD:1306223
    See related
    EnsemblRapid:ENSRNOG00000008912 AllianceGenome:RGD:1306223
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 3'-5' RNA helicase activity; mRNA binding activity; and single-stranded RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U2-type catalytic step 2 spliceosome. Orthologous to human AQR (aquarius intron-binding spliceosomal factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 143.3), Spleen (RPKM 127.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aqr in Genome Data Viewer
    Location:
    3q35
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (121329287..121399375, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (100874987..100945026, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (105570399..105640431, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101628 Neighboring gene gap junction protein, delta 2 Neighboring gene actin, alpha, cardiac muscle 1 Neighboring gene zinc finger protein 770 Neighboring gene uncharacterized LOC120101629

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Splicing and beyond: the many faces of the Prp19 complex. Chanarat S, et al. Biochim Biophys Acta, 2013 Oct. PMID 23742842
    2. Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Bertram K, et al. Nature, 2017 Feb 16. PMID 28076346
    3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5' RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA helicase aquarius
    Names
    aquarius homolog
    intron-binding protein aquarius
    NP_001094457.1
    XP_063140346.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100987.1 → NP_001094457.1  RNA helicase aquarius

      See identical proteins and their annotated locations for NP_001094457.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133727
      UniProtKB/TrEMBL
      A3KNA0, A6HP78, A6HP79, F7FAP1
      Related
      ENSRNOP00000011950.5, ENSRNOT00000011952.8
      Conserved Domains (4) summary
      pfam13086
      Location:805 → 1107
      AAA_11; AAA domain
      pfam13245
      Location:808 → 880
      AAA_19; Part of AAA domain
      pfam16399
      Location:18 → 802
      Aquarius_N; Intron-binding protein aquarius N-terminus
      cl22977
      Location:1115 → 1304
      UvrD_C_2; UvrD-like helicase C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      121329287..121399375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284276.1 → XP_063140346.1  RNA helicase aquarius isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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