Ube2q2 ubiquitin conjugating enzyme E2 Q2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ube2q2provided by RGD
Official Full Name: ubiquitin conjugating enzyme E2 Q2provided by RGD
Primary source: RGD:1307680
See related: EnsemblRapid:ENSRNOG00000014529 AllianceGenome:RGD:1307680
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307680
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K48-linked ubiquitination. Orthologous to human UBE2Q2 (ubiquitin conjugating enzyme E2 Q2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 200.8), Brain (RPKM 194.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (64414502..64474425)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (55518402..55578342)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (59709972..59754102)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin conjugating enzyme activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 Q2

Names: ubiquitin-conjugating enzyme E2Q (putative) 2; ubiquitin-conjugating enzyme E2Q family member 2

NP_001385807.1

EC 6.3.2.19

XP_038938304.2

EC 6.3.2.19

XP_038938306.2

EC 6.3.2.19

XP_038938307.1

EC 6.3.2.19

XP_038938308.1

EC 6.3.2.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398878.1 → NP_001385807.1 ubiquitin-conjugating enzyme E2 Q2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6J4P1, D4A1G2

Conserved Domains (1) summary

cl00154
Location:208 → 364

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

64414502..64474425

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082376.2 → XP_038938304.2 ubiquitin-conjugating enzyme E2 Q2 isoform X1

Related

ENSRNOP00000111034.1, ENSRNOT00000123315.1
XM_039082378.2 → XP_038938306.2 ubiquitin-conjugating enzyme E2 Q2 isoform X2
XM_039082379.2 → XP_038938307.1 ubiquitin-conjugating enzyme E2 Q2 isoform X3

UniProtKB/TrEMBL

A0A8I6AE35

Conserved Domains (1) summary

cl00154
Location:173 → 329

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
XM_039082380.2 → XP_038938308.1 ubiquitin-conjugating enzyme E2 Q2 isoform X4

Conserved Domains (1) summary

cd00195
Location:139 → 295

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...