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    Ero1b endoplasmic reticulum oxidoreductase 1 beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364755, updated on 9-Dec-2024

    Summary

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    Symbol
    Ero1bprovided by RGD
    Full Name
    endoplasmic reticulum oxidoreductase 1 betaprovided by RGD
    Primary source
    RGD:1563548
    See related
    EnsemblRapid:ENSRNOG00000002609 AllianceGenome:RGD:1563548
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ero1lb; RGD1563548
    Summary
    Predicted to enable protein-disulfide reductase activity and thiol oxidase activity. Predicted to be involved in protein folding in endoplasmic reticulum. Predicted to act upstream of or within several processes, including cell redox homeostasis; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and protein maturation. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum lumen and endoplasmic reticulum membrane. Orthologous to human ERO1B (endoplasmic reticulum oxidoreductase 1 beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 233.1), Spleen (RPKM 124.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ero1b in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (92913696..92987401)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (85861086..86003244)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (90709394..90783110, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene sperm motility kinase X-like Neighboring gene EDAR associated via death domain Neighboring gene G protein-coupled receptor 137B Neighboring gene nidogen 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis. Zito E, et al. J Cell Biol, 2010 Mar 22. PMID 20308425, Free PMC Article
    2. Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox. Avezov E, et al. J Cell Biol, 2013 Apr 15. PMID 23589496, Free PMC Article
    3. Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice. Zito E, et al. Mol Cell, 2012 Oct 12. PMID 22981861, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables disulfide oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thiol oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within insulin processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in insulin processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptidyl-proline hydroxylation to 4-hydroxy-L-proline ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein maturation by protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ERO1-like protein beta
    Names
    ERO1-like beta
    endoplasmic reticulum oxidoreductase beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191893.2 → NP_001178822.1  ERO1-like protein beta isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6A593
      Related
      ENSRNOP00000086032.2, ENSRNOT00000113322.2
      Conserved Domains (1) summary
      pfam04137
      Location:56 → 449
      ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

    2. NM_001415676.1 → NP_001402605.1  ERO1-like protein beta isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6A593
      Related
      ENSRNOP00000075470.3, ENSRNOT00000085669.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      92913696..92987401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095982.2 → XP_038951910.1  ERO1-like protein beta isoform X2

      UniProtKB/TrEMBL
      A0A8I5YBH6, A0A8I6GLG0
      Conserved Domains (1) summary
      pfam04137
      Location:23 → 421
      ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

    2. XM_008771876.4 → XP_008770098.1  ERO1-like protein beta isoform X2

      UniProtKB/TrEMBL
      A0A8I5YBH6, A0A8I6GLG0
      Related
      ENSRNOP00000096082.1, ENSRNOT00000100413.2
      Conserved Domains (1) summary
      pfam04137
      Location:23 → 421
      ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

    3. XM_063276672.1 → XP_063132742.1  ERO1-like protein beta isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAP1, A0A8I6A593

    4. XM_063276675.1 → XP_063132745.1  ERO1-like protein beta isoform X5

      UniProtKB/TrEMBL
      A0A8I6A3H1
      Related
      ENSRNOP00000086364.1, ENSRNOT00000115419.2

    5. XM_063276674.1 → XP_063132744.1  ERO1-like protein beta isoform X4

      UniProtKB/TrEMBL
      A6KTE1

    6. XM_063276673.1 → XP_063132743.1  ERO1-like protein beta isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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