Ftcd formimidoyltransferase cyclodeaminase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ftcdprovided by RGD
Official Full Name: formimidoyltransferase cyclodeaminaseprovided by RGD
Primary source: RGD:70915
See related: EnsemblRapid:ENSRNOG00000001261 AllianceGenome:RGD:70915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; and microtubule binding activity. Involved in cytoskeleton organization. Located in Golgi membrane; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Human ortholog(s) of this gene implicated in glutamate formiminotransferase deficiency. Orthologous to human FTCD (formimidoyltransferase cyclodeaminase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1469.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (12054710..12068219, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (12055203..12068717, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (12806957..12820466, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Determination of the FTCD structure by X-ray crystallography and electron cryomicroscopy revealed that the eight subunits, each composed of distinct FT and CD domains, are arranged like a square doughnut
Title: Structure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer.
FTCD is a potent modulator of the vimentin IF cytoskeleton
Title: A novel type of regulation of the vimentin intermediate filament cytoskeleton by a Golgi protein.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:259080 (e-PCR)
- UniSTS:259080

Ftcd (e-PCR), detects polymorphism
- UniSTS:259080

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables folic acid binding	IEA Inferred from Electronic Annotation more info
enables formimidoyltetrahydrofolate cyclodeaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables formimidoyltetrahydrofolate cyclodeaminase activity	ISO Inferred from Sequence Orthology more info
enables formimidoyltetrahydrofolate cyclodeaminase activity	TAS Traceable Author Statement more info	PubMed
enables glutamate formimidoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate formimidoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glutamate formimidoyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables intermediate filament binding	TAS Traceable Author Statement more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-histidine catabolic process to glutamate and formamide	IEA Inferred from Electronic Annotation more info
involved_in L-histidine catabolic process to glutamate and formate	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in smooth endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: formimidoyltransferase-cyclodeaminase

Names: 58 kDa microtubule-binding protein; formiminotransferase cyclodeaminase

NP_446019.1

EC 2.1.2.5

EC 4.3.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053567.2 → NP_446019.1 formimidoyltransferase-cyclodeaminase

See identical proteins and their annotated locations for NP_446019.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

O88618, Q5BKB7

UniProtKB/TrEMBL

A6JKC1

Related

ENSRNOP00000001699.3, ENSRNOT00000001699.8

Conserved Domains (4) summary

TIGR02024
Location:1 → 328

FtcD; glutamate formiminotransferase

pfam02971
Location:181 → 324

FTCD; Formiminotransferase domain

pfam04961
Location:339 → 519

FTCD_C; Formiminotransferase-cyclodeaminase

pfam07837
Location:7 → 179

FTCD_N; Formiminotransferase domain, N-terminal subdomain