Slc22a25 solute carrier family 22, member 25 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc22a25provided by RGD
Official Full Name: solute carrier family 22, member 25provided by RGD
Primary source: RGD:621104
See related: EnsemblRapid:ENSRNOG00000017964 AllianceGenome:RGD:621104
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ust1; Ust1r; Slc22a9
Summary: Predicted to enable short-chain fatty acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in hormone transport; short-chain fatty acid transmembrane transport; and sodium-independent organic anion transport. Predicted to be located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A9 (solute carrier family 22 member 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 783.9) See more
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Genomic context

Location:: 1q43

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (214767837..214956535, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (205338698..205498486, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (224596886..224698512, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oat8 was identified as the n58 kDa protein that in the collecting duct colocalized with the V-ATPase in plasma membranes and intracellular vesicles in various subtypes of intercalated cells
Title: Functional and immunochemical characterization of a novel organic anion transporter Oat8 (Slc22a9) in rat renal collecting duct.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables short-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium-independent organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in hormone transport	ISO Inferred from Sequence Orthology more info
involved_in organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in short-chain fatty acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium-independent organic anion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 22 member 24

Names: integral membrane transport UST1r; putative integral membrane transport UST1r; solute carrier family 22 (organic anion/cation transporter), member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138908.3 → NP_620263.1 solute carrier family 22 member 24

See identical proteins and their annotated locations for NP_620263.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

F7ETA0, O70609

Related

ENSRNOP00000024234.2, ENSRNOT00000024234.8

Conserved Domains (3) summary

cd06174
Location:125 → 506

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:11 → 525

2A0119; cation transport protein

cl00214
Location:39 → 85

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

214767837..214956535 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093137.2 → XP_038949065.1 solute carrier family 22 member 24 isoform X1

Conserved Domains (1) summary

cl28910
Location:1 → 324

MFS; Major Facilitator Superfamily