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    Tulp4 TUB like protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 68842, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tulp4provided by MGI
    Official Full Name
    TUB like protein 4provided by MGI
    Primary source
    MGI:MGI:1916092
    See related
    Ensembl:ENSMUSG00000034377 AllianceGenome:MGI:1916092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tusp; 1110057P05Rik; 2210038L17Rik
    Summary
    Predicted to be involved in protein ubiquitination. Predicted to be located in cytoplasm. Is expressed in incisor; intestine smooth muscle circular layer; nervous system; sensory organ; and vibrissa. Orthologous to human TULP4 (TUB like protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 27.4), CNS E14 (RPKM 24.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tulp4 in Genome Data Viewer
    Location:
    17 A1; 17 3.72 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (6156528..6290912)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (6106253..6240637)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene synaptojanin 2 Neighboring gene STARR-seq mESC enhancer starr_41712 Neighboring gene serine active site containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E9051 Neighboring gene STARR-positive B cell enhancer ABC_E8652 Neighboring gene general transcription factor IIH, polypeptide 5 Neighboring gene STARR-seq mESC enhancer starr_41713 Neighboring gene fibrillarin, pseudogene 2 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41714 Neighboring gene fibrillarin pseudogene Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_41716 Neighboring gene transmembrane protein 181A Neighboring gene dynein light chain Tctex-type 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Effects of Tulp4 deficiency on murine embryonic development and adult phenotype. Jäger R, et al. Microsc Res Tech, 2024 Apr. PMID 38115643
    2. Circ-Tulp4 promotes β-cell adaptation to lipotoxicity by regulating soat1 expression. Wu L, et al. J Mol Endocrinol, 2020 Nov. PMID 33064661, Free PMC Article
    3. Experimental and computational approaches yield a high-resolution, 1-Mb physical map of the region harboring the mouse t haplotype sterility factor, tcs1. Planchart A, et al. Mamm Genome, 2001 Aug. PMID 11471064
    4. Molecular cloning and characterization of the mouse and human TUSP gene, a novel member of the tubby superfamily. Li QZ, et al. Gene, 2001 Aug 8. PMID 11595174
    5. Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development. Rybiczka-Tešulov M, et al. Nat Commun, 2024 Aug 8. PMID 39117691, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of Tulp4 deficiency on murine embryonic development and adult phenotype.
      Title: Effects of Tulp4 deficiency on murine embryonic development and adult phenotype.
    2. Circ-Tulp4 promotes beta-cell adaptation to lipotoxicity by regulating soat1 expression.
      Title: Circ-Tulp4 promotes β-cell adaptation to lipotoxicity by regulating soat1 expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tubby-related protein 4
    Names
    tubby like protein 4
    tubby super-family protein
    tubby superfamily protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103181.1 → NP_001096651.1  tubby-related protein 4 isoform b

      See identical proteins and their annotated locations for NP_001096651.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' terminal exon, which results in a downstream translation start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK004288, AK147643, BB641651, BP764413, BU510078, BY244468, CJ071434, CN669880, CX219752
      Consensus CDS
      CCDS49934.1
      UniProtKB/TrEMBL
      Q3UH13
      Related
      ENSMUSP00000123218.2, ENSMUST00000149756.8
      Conserved Domains (3) summary
      PHA03247
      Location:813 → 1118
      PHA03247; large tegument protein UL36; Provisional
      pfam01167
      Location:1277 → 1347
      Tub; Tub family
      cl02533
      Location:180 → 215
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    2. NM_054040.3 → NP_473381.1  tubby-related protein 4 isoform a

      See identical proteins and their annotated locations for NP_473381.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AF219945, AK004288, AK039439, AK173165, BP764413, BU510078, CN669880, CX219752
      Consensus CDS
      CCDS28370.1
      UniProtKB/Swiss-Prot
      B2RQP8, Q8CA75, Q922C2, Q9JIL5
      Related
      ENSMUSP00000049248.3, ENSMUST00000039655.3
      Conserved Domains (5) summary
      COG2319
      Location:67 → 217
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:85 → 123
      7WD40; WD40 repeat [structural motif]
      pfam01167
      Location:1470 → 1540
      Tub; Tub family
      pfam03154
      Location:925 → 1334
      Atrophin-1; Atrophin-1 family
      cl02533
      Location:373 → 408
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      6156528..6290912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250031.1 → XP_030105891.1  tubby-related protein 4 isoform X1

      Conserved Domains (5) summary
      COG2319
      Location:67 → 217
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:85 → 123
      7WD40; WD40 repeat [structural motif]
      pfam01167
      Location:1513 → 1583
      Tub; Tub family
      pfam03154
      Location:968 → 1377
      Atrophin-1; Atrophin-1 family
      cl02533
      Location:373 → 408
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    2. XM_030250033.1 → XP_030105893.1  tubby-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      B2RQP8, Q8CA75, Q922C2, Q9JIL5
      Conserved Domains (5) summary
      COG2319
      Location:67 → 217
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:85 → 123
      7WD40; WD40 repeat [structural motif]
      pfam01167
      Location:1470 → 1540
      Tub; Tub family
      pfam03154
      Location:925 → 1334
      Atrophin-1; Atrophin-1 family
      cl02533
      Location:373 → 408
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    3. XM_030250034.1 → XP_030105894.1  tubby-related protein 4 isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:856 → 1161
      PHA03247; large tegument protein UL36; Provisional
      pfam01167
      Location:1320 → 1390
      Tub; Tub family
      cl02533
      Location:180 → 215
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    4. XM_030250035.1 → XP_030105895.1  tubby-related protein 4 isoform X5

      UniProtKB/TrEMBL
      Q3UH13
      Conserved Domains (3) summary
      PHA03247
      Location:813 → 1118
      PHA03247; large tegument protein UL36; Provisional
      pfam01167
      Location:1277 → 1347
      Tub; Tub family
      cl02533
      Location:180 → 215
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    5. XM_006523248.4 → XP_006523311.1  tubby-related protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006523311.1

      Conserved Domains (5) summary
      COG2319
      Location:67 → 217
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:85 → 123
      7WD40; WD40 repeat [structural motif]
      pfam01167
      Location:1513 → 1583
      Tub; Tub family
      pfam03154
      Location:968 → 1377
      Atrophin-1; Atrophin-1 family
      cl02533
      Location:373 → 408
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    6. XM_030250032.1 → XP_030105892.1  tubby-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      B2RQP8, Q8CA75, Q922C2, Q9JIL5
      Conserved Domains (5) summary
      COG2319
      Location:67 → 217
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:85 → 123
      7WD40; WD40 repeat [structural motif]
      pfam01167
      Location:1470 → 1540
      Tub; Tub family
      pfam03154
      Location:925 → 1334
      Atrophin-1; Atrophin-1 family
      cl02533
      Location:373 → 408
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    7. XM_036160775.1 → XP_036016668.1  tubby-related protein 4 isoform X3

      Conserved Domains (5) summary
      PHA03247
      Location:995 → 1326
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:86 → 121
      7WD40; WD40 repeat [structural motif]
      pfam01167
      Location:1459 → 1529
      Tub; Tub family
      cl02533
      Location:319 → 354
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl29593
      Location:78 → 164
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_006523252.4 → XP_006523315.1  tubby-related protein 4 isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:856 → 1161
      PHA03247; large tegument protein UL36; Provisional
      pfam01167
      Location:1320 → 1390
      Tub; Tub family
      cl02533
      Location:180 → 215
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    9. XM_030250028.2 → XP_030105888.1  tubby-related protein 4 isoform X1

      Conserved Domains (5) summary
      COG2319
      Location:67 → 217
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:85 → 123
      7WD40; WD40 repeat [structural motif]
      pfam01167
      Location:1513 → 1583
      Tub; Tub family
      pfam03154
      Location:968 → 1377
      Atrophin-1; Atrophin-1 family
      cl02533
      Location:373 → 408
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    10. XM_030250030.2 → XP_030105890.1  tubby-related protein 4 isoform X1

      Conserved Domains (5) summary
      COG2319
      Location:67 → 217
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:85 → 123
      7WD40; WD40 repeat [structural motif]
      pfam01167
      Location:1513 → 1583
      Tub; Tub family
      pfam03154
      Location:968 → 1377
      Atrophin-1; Atrophin-1 family
      cl02533
      Location:373 → 408
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    11. XM_030250029.2 → XP_030105889.1  tubby-related protein 4 isoform X1

      Conserved Domains (5) summary
      COG2319
      Location:67 → 217
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:85 → 123
      7WD40; WD40 repeat [structural motif]
      pfam01167
      Location:1513 → 1583
      Tub; Tub family
      pfam03154
      Location:968 → 1377
      Atrophin-1; Atrophin-1 family
      cl02533
      Location:373 → 408
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    12. XM_006523249.5 → XP_006523312.1  tubby-related protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006523312.1

      Conserved Domains (5) summary
      COG2319
      Location:67 → 217
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:85 → 123
      7WD40; WD40 repeat [structural motif]
      pfam01167
      Location:1513 → 1583
      Tub; Tub family
      pfam03154
      Location:968 → 1377
      Atrophin-1; Atrophin-1 family
      cl02533
      Location:373 → 408
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    13. XM_030250027.2 → XP_030105887.1  tubby-related protein 4 isoform X1

      Conserved Domains (5) summary
      COG2319
      Location:67 → 217
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:85 → 123
      7WD40; WD40 repeat [structural motif]
      pfam01167
      Location:1513 → 1583
      Tub; Tub family
      pfam03154
      Location:968 → 1377
      Atrophin-1; Atrophin-1 family
      cl02533
      Location:373 → 408
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    14. XM_006523251.5 → XP_006523314.1  tubby-related protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006523314.1

      UniProtKB/Swiss-Prot
      B2RQP8, Q8CA75, Q922C2, Q9JIL5
      Conserved Domains (5) summary
      COG2319
      Location:67 → 217
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:85 → 123
      7WD40; WD40 repeat [structural motif]
      pfam01167
      Location:1470 → 1540
      Tub; Tub family
      pfam03154
      Location:925 → 1334
      Atrophin-1; Atrophin-1 family
      cl02533
      Location:373 → 408
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    15. XM_036160774.1 → XP_036016667.1  tubby-related protein 4 isoform X3

      Conserved Domains (5) summary
      PHA03247
      Location:995 → 1326
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:86 → 121
      7WD40; WD40 repeat [structural motif]
      pfam01167
      Location:1459 → 1529
      Tub; Tub family
      cl02533
      Location:319 → 354
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl29593
      Location:78 → 164
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033529.1: Suppressed sequence

      Description
      NM_001033529.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIL5.1 GenPept UniProtKB/Swiss-Prot:Q9JIL5

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