Cd59a CD59a antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd59aprovided by MGI
Official Full Name: CD59a antigenprovided by MGI
Primary source: MGI:MGI:109177
See related: Ensembl:ENSMUSG00000032679 AllianceGenome:MGI:109177
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd59; MACIF; MAC-IP
Summary: Predicted to enable complement binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of fibroblast growth factor production; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Acts upstream of or within negative regulation of activation of membrane attack complex. Located in external side of plasma membrane. Is expressed in several structures, including Meckel's cartilage; nervous system; neural retina; skeleton; and testis. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 34.6), subcutaneous fat pad adult (RPKM 26.7) and 24 other tissues See more
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Genomic context

Location:: 2 E2; 2 54.53 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (103926177..103945755)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (104095753..104115410)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data (including data from studies using knockout mice) suggest that CD59a, CD59b, and ApoE are involved in development of diabetes-induced atherosclerosis; here, deficiency of CD59a/CD59b (in ApoE deficient mice) accelerates development of atherosclerosis in mice with type 1 diabetes. (CD59a = CD59a antigen; CD59b = CD59b antigen; ApoE = apolipoprotein E)
Title: Deficiency of the complement regulatory protein CD59 accelerates the development of diabetes-induced atherosclerosis in mice.
Varicella-zoster virus infection upregulates host CD59 expression in a tissue-specific manner.
Title: Modulation of host CD59 expression by varicella-zoster virus in human xenografts in vivo.
This study support a role of Cd59a in controlling the innate immune status of the RPE-choroidal complex and emphasizes the particular vulnerability of this ocular compartment to the dysregulation of alternative complement pathway during aging
Title: Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age.
results implicate CD59 as an important modulator of the immune response in NMO, and provide a novel animal model of NMO that closely recapitulates human NMO pathology.
Title: Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59.
Soluble forms of CD59 (sCD59) have been investigated in mouse laser-induced choroidal neovascularization, a model for "wet" age related macular degeneration.
Title: The complement regulatory protein CD59: insights into attenuation of choroidal neovascularization.
both CD59 and C-PC could inhibit the progress of atherosclerosis, and the anti-atherosclerotic effects of C-PC might be fulfilled by promoting CD59 expression, preventing smooth muscle cell proliferation and the apoptosis of endothelial cells
Title: CD59 underlines the antiatherosclerotic effects of C-phycocyanin on mice.
CD59a inhibits systemic autoimmunity in MRL/lpr mice through a complement-independent mechanism.
Title: Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice.
While the connection between CFH deficiency and failure to upregulate CD59a remains unknown, these results suggest that expression of CD59 is tissue-specific and that neuroretinal regulation depends on CFH.
Title: Complement factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice.
Actively immunized experimental autoimmune myasthenia gravis mice deficient in either CD55 or CD59 showed significant differences in adaptive immune responses and worsened disease outcome associated with increased levels of serum cytokines, modified production of acetylcholine receptor antibodies, and more complement deposition at the neuromuscular junction.
Title: DAF/CD55 and Protectin/CD59 modulate adaptive immunity and disease outcome in experimental autoimmune myasthenia gravis.
HBx can up-regulate CD59 and Crry expression in podocytes through activating the P38 pathway.
Title: [Hepatitis B virus X protein upregulates the expression of CD59 and Crry in mouse podocytes].

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Markers

Cd59a (e-PCR), detects polymorphism
- UniSTS:181817

Cd59a (e-PCR), detects polymorphism
- UniSTS:525888

Cd59a (e-PCR), detects polymorphism
- UniSTS:547998

Cd59a (e-PCR), detects polymorphism
- UniSTS:547999

Cd59a (e-PCR), detects polymorphism
- UniSTS:548000

Cd59a (e-PCR), detects polymorphism
- UniSTS:548001

Cd59a (e-PCR), detects polymorphism
- UniSTS:548002

Cd59a (e-PCR), detects polymorphism
- UniSTS:141291

AA987121 (e-PCR)
- UniSTS:178667

NoName (e-PCR)
- UniSTS:234477

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables complement binding	IBA Inferred from Biological aspect of Ancestor more info
enables complement binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of activation of membrane attack complex	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of activation of membrane attack complex	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of activation of membrane attack complex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of activation of membrane attack complex	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of complement activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast growth factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of complement activation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in compact myelin	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD59A glycoprotein

Names: CD59 antigen; MAC-inhibitory protein; membrane attack complex inhibition factor; protectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111060.3 → NP_001104530.1 CD59A glycoprotein precursor

See identical proteins and their annotated locations for NP_001104530.1

Status: VALIDATED

Source sequence(s)

BX813317

Consensus CDS

CCDS16487.1

UniProtKB/Swiss-Prot

O55186, Q542R7

UniProtKB/TrEMBL

A2BI31, Q920G6

Related

ENSMUSP00000132774.2, ENSMUST00000168176.8

Conserved Domains (1) summary

smart00134
Location:24 → 100

LU; Ly-6 antigen / uPA receptor -like domain
NM_001416923.1 → NP_001403852.1 CD59A glycoprotein precursor

Status: VALIDATED

Source sequence(s)

BX813317

UniProtKB/Swiss-Prot

O55186, Q542R7

UniProtKB/TrEMBL

A2BI31
NM_001416924.1 → NP_001403853.1 CD59A glycoprotein precursor

Status: VALIDATED

Source sequence(s)

BX813317

UniProtKB/Swiss-Prot

O55186, Q542R7

UniProtKB/TrEMBL

A2BI31
NM_001416925.1 → NP_001403854.1 CD59A glycoprotein precursor

Status: VALIDATED

Source sequence(s)

BX813317

UniProtKB/Swiss-Prot

O55186, Q542R7

UniProtKB/TrEMBL

A2BI31
NM_007652.6 → NP_031678.1 CD59A glycoprotein precursor

See identical proteins and their annotated locations for NP_031678.1

Status: VALIDATED

Source sequence(s)

BX813317

Consensus CDS

CCDS16487.1

UniProtKB/Swiss-Prot

O55186, Q542R7

UniProtKB/TrEMBL

A2BI31, Q920G6

Related

ENSMUSP00000048041.6, ENSMUST00000040423.12

Conserved Domains (1) summary

smart00134
Location:24 → 100

LU; Ly-6 antigen / uPA receptor -like domain