S100a3 S100 calcium binding protein A3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: S100a3provided by MGI
Official Full Name: S100 calcium binding protein A3provided by MGI
Primary source: MGI:MGI:1338849
See related: Ensembl:ENSMUSG00000001021 AllianceGenome:MGI:1338849
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: S100E
Summary: Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Located in collagen-containing extracellular matrix. Is expressed in vibrissa. Orthologous to human S100A3 (S100 calcium binding protein A3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.26 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (90467571..90510922)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (90560356..90602706)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S100A3 is a new target gene of Kaiso in mouse skin
Title: [S100A3 is a new target gene of Kaiso in mouse skin].

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355597.2 → NP_001342526.1 protein S100-A3

Status: VALIDATED

Source sequence(s)

AC160552

Consensus CDS

CCDS17537.1

UniProtKB/Swiss-Prot

P56566, P62818

UniProtKB/TrEMBL

Q496W1

Related

ENSMUSP00000142747.2, ENSMUST00000200508.5

Conserved Domains (1) summary

cd00213
Location:4 → 90

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
NM_001355600.2 → NP_001342529.1 protein S100-A3

Status: VALIDATED

Source sequence(s)

AC160552

Consensus CDS

CCDS17537.1

UniProtKB/Swiss-Prot

P56566, P62818

UniProtKB/TrEMBL

Q496W1

Related

ENSMUSP00000142334.2, ENSMUST00000200290.5

Conserved Domains (1) summary

cd00213
Location:4 → 90

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
NM_001355602.2 → NP_001342531.1 protein S100-A3

Status: VALIDATED

Source sequence(s)

AC160552

Consensus CDS

CCDS17537.1

UniProtKB/Swiss-Prot

P56566, P62818

UniProtKB/TrEMBL

Q496W1

Conserved Domains (1) summary

cd00213
Location:4 → 90

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
NM_001410568.1 → NP_001397497.1 protein S100-A3

Status: VALIDATED

Source sequence(s)

AC160552

UniProtKB/Swiss-Prot

P56566, P62818

UniProtKB/TrEMBL

Q496W1
NM_001410569.1 → NP_001397498.1 protein S100-A3

Status: VALIDATED

Source sequence(s)

AC160552

UniProtKB/Swiss-Prot

P56566, P62818

UniProtKB/TrEMBL

Q496W1
NM_001410570.1 → NP_001397499.1 protein S100-A3

Status: VALIDATED

Source sequence(s)

AC160552

UniProtKB/Swiss-Prot

P56566, P62818

UniProtKB/TrEMBL

Q496W1
NM_011310.3 → NP_035440.1 protein S100-A3

See identical proteins and their annotated locations for NP_035440.1

Status: VALIDATED

Source sequence(s)

AC160552

Consensus CDS

CCDS17537.1

UniProtKB/Swiss-Prot

P56566, P62818

UniProtKB/TrEMBL

Q496W1

Related

ENSMUSP00000001047.8, ENSMUST00000001047.8

Conserved Domains (1) summary

cd00213
Location:4 → 90

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

90467571..90510922

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162967.1 → XP_036018860.1 protein S100-A3 isoform X1

Conserved Domains (1) summary

cd00213
Location:45 → 115

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
XM_011240047.2 → XP_011238349.1 protein S100-A3 isoform X2

See identical proteins and their annotated locations for XP_011238349.1

UniProtKB/Swiss-Prot

P56566, P62818

UniProtKB/TrEMBL

Q496W1

Conserved Domains (1) summary

cd00213
Location:4 → 90

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
XM_030252482.2 → XP_030108342.1 protein S100-A3 isoform X2

UniProtKB/Swiss-Prot

P56566, P62818

UniProtKB/TrEMBL

Q496W1

Conserved Domains (1) summary

cd00213
Location:4 → 90

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...