Gngt1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gngt1provided by MGI
Official Full Name: guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1provided by MGI
Primary source: MGI:MGI:109165
See related: Ensembl:ENSMUSG00000029663 AllianceGenome:MGI:109165
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gng1; G(y)1; Hg3g1
Summary: Predicted to enable G-protein beta-subunit binding activity and GTPase activity. Acts upstream of or within eye photoreceptor cell development; phototransduction; and protein localization. Predicted to be located in photoreceptor inner segment and photoreceptor outer segment. Predicted to be part of heterotrimeric G-protein complex. Is expressed in brain; retina; retina outer nuclear layer; and spleen. Orthologous to human GNGT1 (G protein subunit gamma transducin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 1.81 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (3989082..3997441)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (3989082..3997436)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that synaptosome associated protein 25 (SNAP25)Delta3 mutation has a twofold reduction in GTP-binding protein beta/gamma (Gbetagamma) binding.
Title: Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.
During corticogenesis, a cilium-transduced, noncanonical IGF-1R-Gbetagamma-phospho(T94)Tctex-1 signaling pathway promotes the proliferation of neural progenitors through modulation of ciliary resorption and G1 length.
Title: IGF-1 activates a cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression.
Data indicate that a decrease in the Gbeta1 production in Ggamma1 knockout rods resulted in a significant reduction in proteasomal overload and caused a striking reversal of photoreceptor degeneration.
Title: Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration.
ectopically expressed cTalpha 1) forms a heterotrimeric complex with rod Gbeta(1)gamma(1), and substitutes equally for rTalpha in generating photoresponses initiated by either rhodopsin or S-cone opsin
Title: Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.
Results suggest a model in which the Gbetagamma dimer that is released as a result of the dissociation from Galpha(o) upon activation of mGluR6 closes the TRPM1 channel, perhaps via a direct interaction.
Title: G-protein-mediated inhibition of the Trp channel TRPM1 requires the Gβγ dimer.
WDR26 is a novel Gbetagamma-binding protein that is required for the efficacy of Gbetagamma signaling and leukocyte migration
Title: The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration.
findings demonstrate that transducin betagamma-complex controls signal amplification of the rod phototransduction cascade and is critical for the ability of rod photoreceptors to function in low light conditions.
Title: G-protein betagamma-complex is crucial for efficient signal amplification in vision.
G protein betagamma subunits stimulate type V and VI adenylyl cyclases
Title: Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

Gngt1 (e-PCR), detects polymorphism
- UniSTS:496690

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta-subunit binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cellular response to hypoxia	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within eye photoreceptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in photoreceptor inner segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: guanine nucleotide-binding protein G(T) subunit gamma-T1

Names: guanine nucleotide binding protein (G protein), gamma 1 subunit; heterotrimeric guanine nucleotide-binding protein 3g1; transducin gamma chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010314.3 → NP_034444.1 guanine nucleotide-binding protein G(T) subunit gamma-T1

See identical proteins and their annotated locations for NP_034444.1

Status: VALIDATED

Source sequence(s)

AC022235, AK020903

Consensus CDS

CCDS39418.1

UniProtKB/Swiss-Prot

Q61012, Q9CR01

Related

ENSMUSP00000031673.6, ENSMUST00000031673.7

Conserved Domains (1) summary

smart00224
Location:12 → 74

GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

3989082..3997441

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321388.3 → XP_017176877.1 guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1

UniProtKB/Swiss-Prot

Q61012, Q9CR01

Conserved Domains (1) summary

smart00224
Location:12 → 74

GGL; G protein gamma subunit-like motifs
XM_017321389.3 → XP_017176878.1 guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1

UniProtKB/Swiss-Prot

Q61012, Q9CR01

Conserved Domains (1) summary

smart00224
Location:12 → 74

GGL; G protein gamma subunit-like motifs
XM_006504986.3 → XP_006505049.1 guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1

See identical proteins and their annotated locations for XP_006505049.1

UniProtKB/Swiss-Prot

Q61012, Q9CR01

Conserved Domains (1) summary

smart00224
Location:12 → 74

GGL; G protein gamma subunit-like motifs