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    Tmem116 transmembrane protein 116 [ Mus musculus (house mouse) ]

    Gene ID: 77462, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem116provided by MGI
    Official Full Name
    transmembrane protein 116provided by MGI
    Primary source
    MGI:MGI:1924712
    See related
    Ensembl:ENSMUSG00000029452 AllianceGenome:MGI:1924712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930406A18Rik; 4930513P12Rik; C030022K24Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in heart; liver; lung; metanephros; and spleen. Orthologous to human TMEM116 (transmembrane protein 116). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 38.8), testis adult (RPKM 10.9) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem116 in Genome Data Viewer
    Location:
    5 F; 5 61.81 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121590643..121656601)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121452580..121518188)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1688 Neighboring gene N(alpha)-acetyltransferase 25, NatB auxiliary subunit Neighboring gene STARR-seq mESC enhancer starr_14257 Neighboring gene STARR-positive B cell enhancer ABC_E6373 Neighboring gene STARR-positive B cell enhancer ABC_E6374 Neighboring gene endoplasmic reticulum protein 29 Neighboring gene STARR-positive B cell enhancer ABC_E4785 Neighboring gene mitogen-activated protein kinase 3 pseudogene Neighboring gene a disintegrin and metallopeptidase domain 1b Neighboring gene a disintegrin and metallopeptidase domain 1a Neighboring gene MAP kinase-activated protein kinase 5 Neighboring gene STARR-seq mESC enhancer starr_14259 Neighboring gene STARR-positive B cell enhancer ABC_E9092

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway. Zhang S, et al. Cell Death Dis, 2021 Nov 16. PMID 34789718, Free PMC Article
    2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway.
      Title: TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 116

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161626.1 → NP_001155098.1  transmembrane protein 116 isoform 2

      See identical proteins and their annotated locations for NP_001155098.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC129215, AK021099, CK127968, DV658154
      Consensus CDS
      CCDS51641.1
      UniProtKB/TrEMBL
      G3X901
      Related
      ENSMUSP00000031405.6, ENSMUST00000031405.12

    2. NM_001161627.1 → NP_001155099.1  transmembrane protein 116 isoform 1

      See identical proteins and their annotated locations for NP_001155099.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC129215, AK021099, CK127968
      Consensus CDS
      CCDS51640.1
      UniProtKB/TrEMBL
      G3X9M9
      Related
      ENSMUSP00000091917.5, ENSMUST00000094357.11

    3. NM_029912.2 → NP_084188.1  transmembrane protein 116 isoform 3

      See identical proteins and their annotated locations for NP_084188.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC129215, AK021099, DV658154
      Consensus CDS
      CCDS19635.1
      UniProtKB/TrEMBL
      Q8VCT8
      Related
      ENSMUSP00000054232.9, ENSMUST00000060004.15

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      121590643..121656601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254899.2 → XP_030110759.1  transmembrane protein 116 isoform X4

      UniProtKB/TrEMBL
      Q8CA26
      Related
      ENSMUSP00000121579.4, ENSMUST00000156080.8

    2. XM_036165599.1 → XP_036021492.1  transmembrane protein 116 isoform X3

      UniProtKB/TrEMBL
      Q8VCT8

    3. XM_017321173.2 → XP_017176662.1  transmembrane protein 116 isoform X2

    4. XM_017321172.3 → XP_017176661.1  transmembrane protein 116 isoform X1

    5. XM_017321174.3 → XP_017176663.1  transmembrane protein 116 isoform X3

      UniProtKB/TrEMBL
      Q8VCT8

    RNA

    1. XR_001784756.1 RNA Sequence

    2. XR_001784755.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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