Tgm2 transglutaminase 2, C polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tgm2provided by MGI
Official Full Name: transglutaminase 2, C polypeptideprovided by MGI
Primary source: MGI:MGI:98731
See related: Ensembl:ENSMUSG00000037820 AllianceGenome:MGI:98731
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TG2; tTG; G[a]h; tTGas; TGase2
Summary: Enables protein-glutamine gamma-glutamyltransferase activity. Involved in intracellular calcium ion homeostasis; positive regulation of cell adhesion; and regulation of apoptotic cell clearance. Acts upstream of or within branching involved in salivary gland morphogenesis and salivary gland cavitation. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; bone; central nervous system; genitourinary system; and sensory organ. Used to study maturity-onset diabetes of the young. Orthologous to human TGM2 (transglutaminase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in mammary gland adult (RPKM 134.3), lung adult (RPKM 130.8) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 78.72 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (157958325..157988312, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (158116405..158146392, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TG2 participates in pulmonary vascular remodelling by regulating the senescence of pulmonary artery smooth muscle cells.
Title: TG2 participates in pulmonary vascular remodelling by regulating the senescence of pulmonary artery smooth muscle cells.
Transglutaminase 2 knockout mice are protected from bleomycin-induced lung fibrosis with preserved lung function and reduced metabolic derangements.
Title: Transglutaminase 2 knockout mice are protected from bleomycin-induced lung fibrosis with preserved lung function and reduced metabolic derangements.
Lung-specific interleukin 6 mediated transglutaminase 2 activation and cardiopulmonary fibrogenesis.
Title: Lung-specific interleukin 6 mediated transglutaminase 2 activation and cardiopulmonary fibrogenesis.
Piezo1 channel causes lens sclerosis via transglutaminase 2 activation.
Title: Piezo1 channel causes lens sclerosis via transglutaminase 2 activation.
Novel function of transglutaminase 2 in extracellular histone-induced acute lung injury.
Title: Novel function of transglutaminase 2 in extracellular histone-induced acute lung injury.
Increased Osteoclastogenesis in Absence of TG2 Is Reversed by Transglutaminase Inhibition-Evidence for the Role for TG1 in Osteoclast Formation.
Title: Increased Osteoclastogenesis in Absence of TG2 Is Reversed by Transglutaminase Inhibition-Evidence for the Role for TG1 in Osteoclast Formation.
Transglutaminase 2 Facilitates Murine Wound Healing in a Strain-Dependent Manner.
Title: Transglutaminase 2 Facilitates Murine Wound Healing in a Strain-Dependent Manner.
Transglutaminase-2 is critical for corneal epithelial barrier function via positive regulation of Claudin-1.
Title: Transglutaminase-2 is critical for corneal epithelial barrier function via positive regulation of Claudin-1.
Allosteric Activation of Transglutaminase 2 via Inducing an "Open" Conformation for Osteoblast Differentiation.
Title: Allosteric Activation of Transglutaminase 2 via Inducing an "Open" Conformation for Osteoblast Differentiation.
Deletion of Transglutaminase 2 from Mouse Astrocytes Significantly Improves Their Ability to Promote Neurite Outgrowth on an Inhibitory Matrix.
Title: Deletion of Transglutaminase 2 from Mouse Astrocytes Significantly Improves Their Ability to Promote Neurite Outgrowth on an Inhibitory Matrix.

Submit: New GeneRIF Correction See all GeneRIFs (193)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tgm2 (e-PCR), detects polymorphism
- UniSTS:496703

Tgm2 (e-PCR), detects polymorphism
- UniSTS:186756

UniSTS:466074 (e-PCR)
- UniSTS:466074

Tgm2 (e-PCR), detects polymorphism
- UniSTS:466074

Tgm2 (e-PCR), detects polymorphism
- UniSTS:466075

Tgm2 (e-PCR), detects polymorphism
- UniSTS:233961

Tgm2 (e-PCR), detects polymorphism
- UniSTS:233962

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	NAS Non-traceable Author Statement more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	NAS Non-traceable Author Statement more info	PubMed
enables histone dopaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone dopaminyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone serotonyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone serotonyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables peptide histaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables peptide histaminyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide noradrenalinyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-glutamine gamma-glutamyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glutamine gamma-glutamyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-glutamine gamma-glutamyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-glutamine glutaminase activity	ISO Inferred from Sequence Orthology more info
enables protein-glutamine glutaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transaminase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in apoptotic cell clearance	IEA Inferred from Electronic Annotation more info
involved_in apoptotic cell clearance	ISO Inferred from Sequence Orthology more info
involved_in blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in bone development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dopamine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dopamine	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to serotonin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to serotonin	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in dopamine secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endoplasmic reticulum calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptide cross-linking	TAS Traceable Author Statement more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of small GTPase mediated signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein deamination	ISO Inferred from Sequence Orthology more info
involved_in protein deamination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic cell clearance	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within salivary gland cavitation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	ISA Inferred from Sequence Alignment more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	TAS Traceable Author Statement more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein-glutamine gamma-glutamyltransferase 2

Names: C polypeptide; TG(C); TGC; TGase C; TGase II; TGase-2; isopeptidase TGM2; protein-glutamine deamidase TGM2; protein-glutamine dopaminyltransferase TGM2; protein-glutamine histaminyltransferase TGM2; protein-glutamine noradrenalinyltransferase TGM2; protein-glutamine serotonyltransferase TGM2; protein-glutamine-gamma-glutamyltransferase; tissue transglutaminase; transglutaminase C; transglutaminase II; transglutaminase-2

NP_033399.1

EC 2.3.2.13

EC 3.5.1.44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009373.3 → NP_033399.1 protein-glutamine gamma-glutamyltransferase 2

See identical proteins and their annotated locations for NP_033399.1

Status: PROVISIONAL

Source sequence(s)

AL669824

Consensus CDS

CCDS16985.1

UniProtKB/Swiss-Prot

O88901, P21981, Q3TLV2, Q8C217, Q91VG9, Q9R1F7

Related

ENSMUSP00000099411.4, ENSMUST00000103122.10

Conserved Domains (4) summary

smart00460
Location:269 → 361

TGc; Transglutaminase/protease-like homologues

COG1305
Location:273 → 369

YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]

pfam00868
Location:7 → 120

Transglut_N; Transglutaminase family

pfam00927
Location:473 → 572

Transglut_C; Transglutaminase family, C-terminal ig like domain