Mageb16 MAGE family member B16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mageb16provided by MGI
Official Full Name: MAGE family member B16provided by MGI
Primary source: MGI:MGI:1919217
See related: Ensembl:ENSMUSG00000046942 AllianceGenome:MGI:1919217
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2410003J06Rik
Summary: Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including brain; egg cylinder; heart; liver; and reproductive system. Orthologous to human MAGEB16 (MAGE family member B16). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in placenta adult (RPKM 10.9) and testis adult (RPKM 3.3) See more
Orthologs: human all
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Genomic context

Location:: X B; X 38.38 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (78666837..78715041, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (79623231..79671435, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mageb16 (41 kDa) is distributed in cytosol and/or in surface membrane in undifferentiated murine embryonic stem cells (ESCs). A transcriptome study performed at differentiated short hairpin RNA (shRNA)-mediated Mageb16 knockdown (KD) ESCs and scrambled control ESCs until a period of 22 days, revealed that Mageb16 KD ESCs mainly differentiated towards cells expressing mesodermal and cardiovascular lineage - gene markers.
Title: Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235459

NoName (e-PCR)
- UniSTS:493281

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: melanoma-associated antigen B16

Names: MAGE-B16 antigen; Novel MAGE family protein; melanoma antigen family B, 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113734.1 → NP_001107206.1 melanoma-associated antigen B16

See identical proteins and their annotated locations for NP_001107206.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.

Source sequence(s)

AK010362, BY387905, CJ081836

Consensus CDS

CCDS53122.1

UniProtKB/Swiss-Prot

Q3TJP9, Q9CWV4

Related

ENSMUSP00000109649.4, ENSMUST00000114016.10

Conserved Domains (1) summary

pfam01454
Location:217 → 303

MAGE; MAGE family
NM_028025.1 → NP_082301.1 melanoma-associated antigen B16

See identical proteins and their annotated locations for NP_082301.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.

Source sequence(s)

AK010362, BY387905

Consensus CDS

CCDS53122.1

UniProtKB/Swiss-Prot

Q3TJP9, Q9CWV4

Related

ENSMUSP00000087292.4, ENSMUST00000052283.7

Conserved Domains (1) summary

pfam01454
Location:217 → 303

MAGE; MAGE family