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    Zkscan7 zinc finger with KRAB and SCAN domains 7 [ Mus musculus (house mouse) ]

    Gene ID: 382118, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zkscan7provided by MGI
    Official Full Name
    zinc finger with KRAB and SCAN domains 7provided by MGI
    Primary source
    MGI:MGI:3040678
    See related
    Ensembl:ENSMUSG00000063488 AllianceGenome:MGI:3040678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp167
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZKSCAN7 (zinc finger with KRAB and SCAN domains 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 2.2), CNS E14 (RPKM 1.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zkscan7 in Genome Data Viewer
    Location:
    9 F4; 9 73.21 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122715883..122727684)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (122886818..122898619)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6814 Neighboring gene T cell activation inhibitor, mitochondrial Neighboring gene predicted gene, 35549 Neighboring gene zinc finger protein 445 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:122775118-122775301 Neighboring gene zinc finger protein 660 Neighboring gene zinc finger protein 105

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein with KRAB and SCAN domains 7
    Names
    zinc finger protein 167

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177505.2 → NP_001170976.1  zinc finger protein with KRAB and SCAN domains 7

      See identical proteins and their annotated locations for NP_001170976.1

      Status: VALIDATED

      Source sequence(s)
      AC125374
      Consensus CDS
      CCDS52970.1
      UniProtKB/TrEMBL
      E9PVW1
      Related
      ENSMUSP00000071695.6, ENSMUST00000063980.8
      Conserved Domains (6) summary
      smart00431
      Location:46 → 156
      SCAN; leucine rich region
      COG5048
      Location:333 → 702
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:601 → 621
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:487 → 509
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:46 → 133
      SCAN; SCAN domain
      pfam13465
      Location:501 → 526
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      122715883..122727684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155097.1 → XP_036010990.1  zinc finger protein with KRAB and SCAN domains 7 isoform X1

      Conserved Domains (2) summary
      COG5048
      Location:1 → 373
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:269 → 289
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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