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    Cep57l1 centrosomal protein 57-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 103268, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep57l1provided by MGI
    Official Full Name
    centrosomal protein 57-like 1provided by MGI
    Primary source
    MGI:MGI:1915511
    See related
    Ensembl:ENSMUSG00000019813 AllianceGenome:MGI:1915511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cep57R; 2410017P07Rik; 4930484D11Rik
    Summary
    Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be located in cytoplasm and microtubule. Predicted to be active in centrosome. Is expressed in adrenal gland; ovary; and testis. Orthologous to human CEP57L1 (centrosomal protein 57 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 5.8), CNS E11.5 (RPKM 4.2) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cep57l1 in Genome Data Viewer
    Location:
    10 B2; 10 22.69 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (41594836..41686413, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (41718840..41809868, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5730435O14 gene Neighboring gene coiled-coil domain containing 162 Neighboring gene STARR-positive B cell enhancer mm9_chr10:41292844-41293145 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:41339920-41340109 Neighboring gene STARR-positive B cell enhancer ABC_E5128 Neighboring gene microRNA 3473b Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:41472075-41472184 Neighboring gene cDNA sequence BC048559 Neighboring gene STARR-seq mESC enhancer starr_26466 Neighboring gene STARR-seq mESC enhancer starr_26467 Neighboring gene STARR-seq mESC enhancer starr_26468 Neighboring gene STARR-seq mESC enhancer starr_26469 Neighboring gene sestrin 1 Neighboring gene STARR-seq mESC enhancer starr_26471 Neighboring gene armadillo repeat containing 2 Neighboring gene annexin A2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    2. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein CEP57L1
    Names
    centrosomal protein 57kDa-like protein 1
    centrosomal protein of 57 kDa-related protein
    cep57-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243074.1 → NP_001230003.1  centrosomal protein CEP57L1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate upstream start codon. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC115297, AC161426, AK010530, AK012710
      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      Conserved Domains (2) summary
      pfam06657
      Location:281 → 352
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:76 → 241
      Cep57_CLD; Centrosome localization domain of Cep57

    2. NM_001243075.1 → NP_001230004.1  centrosomal protein CEP57L1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate upstream start codon. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC115297, AC161426, AK010530, AK012710
      UniProtKB/TrEMBL
      A0A0R4J2C9
      Related
      ENSMUSP00000141031.2, ENSMUST00000190022.7
      Conserved Domains (2) summary
      pfam06657
      Location:234 → 305
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:76 → 177
      Cep57_CLD; Centrosome localization domain of Cep57

    3. NM_026643.6 → NP_080919.3  centrosomal protein CEP57L1 isoform 2

      See identical proteins and their annotated locations for NP_080919.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC115297, AC161426, AK010530
      Consensus CDS
      CCDS23808.1
      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      UniProtKB/TrEMBL
      B2RR53
      Related
      ENSMUSP00000140389.2, ENSMUST00000187143.7
      Conserved Domains (2) summary
      pfam06657
      Location:254 → 327
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50 → 215
      Cep57_CLD; Centrosome localization domain of Cep57

    4. NM_029132.2 → NP_083408.1  centrosomal protein CEP57L1 isoform 1

      See identical proteins and their annotated locations for NP_083408.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC115297, AC161426, AK010530
      Consensus CDS
      CCDS48549.1
      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      UniProtKB/TrEMBL
      G5E828
      Related
      ENSMUSP00000139509.2, ENSMUST00000186239.7
      Conserved Domains (2) summary
      pfam06657
      Location:283 → 356
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50 → 227
      Cep57_CLD; Centrosome localization domain of Cep57

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      41594836..41686413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155463.1 → XP_036011356.1  centrosomal protein CEP57L1 isoform X6

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      Conserved Domains (2) summary
      pfam06657
      Location:299 → 372
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:66 → 243
      Cep57_CLD; Centrosome localization domain of Cep57

    2. XM_036155471.1 → XP_036011364.1  centrosomal protein CEP57L1 isoform X11

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      Conserved Domains (2) summary
      pfam06657
      Location:270 → 343
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:66 → 231
      Cep57_CLD; Centrosome localization domain of Cep57

    3. XM_036155469.1 → XP_036011362.1  centrosomal protein CEP57L1 isoform X10

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      UniProtKB/TrEMBL
      G5E828
      Conserved Domains (2) summary
      pfam06657
      Location:283 → 356
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50 → 227
      Cep57_CLD; Centrosome localization domain of Cep57

    4. XM_036155479.1 → XP_036011372.1  centrosomal protein CEP57L1 isoform X16

      Conserved Domains (1) summary
      pfam14073
      Location:76 → 254
      Cep57_CLD; Centrosome localization domain of Cep57

    5. XM_036155460.1 → XP_036011353.1  centrosomal protein CEP57L1 isoform X3

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      Conserved Domains (2) summary
      pfam06657
      Location:309 → 382
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:76 → 253
      Cep57_CLD; Centrosome localization domain of Cep57

    6. XM_036155480.1 → XP_036011373.1  centrosomal protein CEP57L1 isoform X17

      Conserved Domains (2) summary
      pfam06657
      Location:158 → 231
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:26 → 102
      Cep57_CLD; Centrosome localization domain of Cep57

    7. XM_036155473.1 → XP_036011366.1  centrosomal protein CEP57L1 isoform X13

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      Conserved Domains (2) summary
      pfam06657
      Location:264 → 337
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:76 → 225
      Cep57_CLD; Centrosome localization domain of Cep57

    8. XM_036155464.1 → XP_036011357.1  centrosomal protein CEP57L1 isoform X7

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      Conserved Domains (2) summary
      pfam06657
      Location:293 → 366
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:76 → 237
      Cep57_CLD; Centrosome localization domain of Cep57

    9. XM_036155481.1 → XP_036011374.1  centrosomal protein CEP57L1 isoform X18

      Conserved Domains (2) summary
      pfam06657
      Location:129 → 202
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:26 → 90
      Cep57_CLD; Centrosome localization domain of Cep57

    10. XM_036155472.1 → XP_036011365.1  centrosomal protein CEP57L1 isoform X12

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      Conserved Domains (2) summary
      pfam06657
      Location:267 → 340
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50 → 211
      Cep57_CLD; Centrosome localization domain of Cep57

    11. XM_036155474.1 → XP_036011367.1  centrosomal protein CEP57L1 isoform X14

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      UniProtKB/TrEMBL
      B2RR53
      Related
      ENSMUSP00000140147.2, ENSMUST00000189770.7
      Conserved Domains (2) summary
      pfam06657
      Location:254 → 327
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50 → 215
      Cep57_CLD; Centrosome localization domain of Cep57

    12. XM_036155482.1 → XP_036011375.1  centrosomal protein CEP57L1 isoform X19

      Conserved Domains (2) summary
      pfam06657
      Location:122 → 195
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:1 → 66
      Cep57_CLD; Centrosome localization domain of Cep57

    13. XM_036155467.1 → XP_036011360.1  centrosomal protein CEP57L1 isoform X10

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      UniProtKB/TrEMBL
      G5E828
      Conserved Domains (2) summary
      pfam06657
      Location:283 → 356
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50 → 227
      Cep57_CLD; Centrosome localization domain of Cep57

    14. XM_036155462.1 → XP_036011355.1  centrosomal protein CEP57L1 isoform X5

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      Conserved Domains (2) summary
      pfam06657
      Location:301 → 374
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:68 → 245
      Cep57_CLD; Centrosome localization domain of Cep57

    15. XM_036155470.1 → XP_036011363.1  centrosomal protein CEP57L1 isoform X10

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      UniProtKB/TrEMBL
      G5E828
      Conserved Domains (2) summary
      pfam06657
      Location:283 → 356
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50 → 227
      Cep57_CLD; Centrosome localization domain of Cep57

    16. XM_036155468.1 → XP_036011361.1  centrosomal protein CEP57L1 isoform X10

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      UniProtKB/TrEMBL
      G5E828
      Conserved Domains (2) summary
      pfam06657
      Location:283 → 356
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50 → 227
      Cep57_CLD; Centrosome localization domain of Cep57

    17. XM_036155476.1 → XP_036011369.1  centrosomal protein CEP57L1 isoform X12

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      Conserved Domains (2) summary
      pfam06657
      Location:267 → 340
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50 → 211
      Cep57_CLD; Centrosome localization domain of Cep57

    18. XM_036155478.1 → XP_036011371.1  centrosomal protein CEP57L1 isoform X15

      Conserved Domains (1) summary
      pfam14073
      Location:102 → 280
      Cep57_CLD; Centrosome localization domain of Cep57

    19. XM_036155459.1 → XP_036011352.1  centrosomal protein CEP57L1 isoform X2

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      Conserved Domains (2) summary
      pfam06657
      Location:319 → 392
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:102 → 263
      Cep57_CLD; Centrosome localization domain of Cep57

    20. XM_036155466.1 → XP_036011359.1  centrosomal protein CEP57L1 isoform X9

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      Conserved Domains (2) summary
      pfam06657
      Location:290 → 363
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:102 → 251
      Cep57_CLD; Centrosome localization domain of Cep57

    21. XM_036155458.1 → XP_036011351.1  centrosomal protein CEP57L1 isoform X1

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      Conserved Domains (2) summary
      pfam06657
      Location:335 → 408
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:102 → 279
      Cep57_CLD; Centrosome localization domain of Cep57

    22. XM_036155461.1 → XP_036011354.1  centrosomal protein CEP57L1 isoform X4

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      Conserved Domains (2) summary
      pfam06657
      Location:306 → 379
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:102 → 267
      Cep57_CLD; Centrosome localization domain of Cep57

    23. XM_036155477.1 → XP_036011370.1  centrosomal protein CEP57L1 isoform X14

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      UniProtKB/TrEMBL
      B2RR53
      Related
      ENSMUSP00000101144.4, ENSMUST00000105505.10
      Conserved Domains (2) summary
      pfam06657
      Location:254 → 327
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50 → 215
      Cep57_CLD; Centrosome localization domain of Cep57

    24. XM_036155475.1 → XP_036011368.1  centrosomal protein CEP57L1 isoform X10

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      UniProtKB/TrEMBL
      G5E828
      Conserved Domains (2) summary
      pfam06657
      Location:283 → 356
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50 → 227
      Cep57_CLD; Centrosome localization domain of Cep57

    25. XM_036155465.1 → XP_036011358.1  centrosomal protein CEP57L1 isoform X8

      UniProtKB/Swiss-Prot
      Q8VDS7, Q9CZE0, Q9D5A1
      Conserved Domains (2) summary
      pfam06657
      Location:292 → 365
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:59 → 236
      Cep57_CLD; Centrosome localization domain of Cep57

    26. XM_036155483.1 → XP_036011376.1  centrosomal protein CEP57L1 isoform X19

      Conserved Domains (2) summary
      pfam06657
      Location:122 → 195
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:1 → 66
      Cep57_CLD; Centrosome localization domain of Cep57
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDS7.1 GenPept UniProtKB/Swiss-Prot:Q8VDS7

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