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    Hnrnph3 heterogeneous nuclear ribonucleoprotein H3 [ Mus musculus (house mouse) ]

    Gene ID: 432467, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hnrnph3provided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein H3provided by MGI
    Primary source
    MGI:MGI:1926462
    See related
    Ensembl:ENSMUSG00000020069 AllianceGenome:MGI:1926462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrph3
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Is expressed in central nervous system and retina. Orthologous to human HNRNPH3 (heterogeneous nuclear ribonucleoprotein H3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 51.4), CNS E14 (RPKM 36.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hnrnph3 in Genome Data Viewer
    Location:
    10 B4; 10 32.52 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62850443..62859764, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63014664..63023980, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62409633-62409742 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene RUN and FYVE domain-containing 2 Neighboring gene STARR-seq mESC enhancer starr_26916 Neighboring gene phenazine biosynthesis-like protein domain containing 2 Neighboring gene predicted gene 16143 Neighboring gene phenazine biosynthesis-like protein domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes. Cho KI, et al. Dis Model Mech, 2017 May 1. PMID 28100513, Free PMC Article
    2. Spatiotemporal regulation of hnRNP M and 2H9 gene expression during mouse embryonic development. Mahé D, et al. Biochim Biophys Acta, 2000 Jul 24. PMID 11004512
    3. A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1. Korff A, et al. J Clin Invest, 2023 Jul 17. PMID 37463454, Free PMC Article
    4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    5. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. effects were accompanied by paracrine and autocrine neuroglial deregulation of hnRNPH3 proteostasis in sciatic nerve and motoneurons, respectively, and post-transcriptional downregulation of metalloproteinase 28 in the sciatic nerve
      Title: Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein H3
    Names
    hnRNP 2H9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079824.1 → NP_001073293.1  heterogeneous nuclear ribonucleoprotein H3 isoform 1

      See identical proteins and their annotated locations for NP_001073293.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC113107, AI666703, BQ443117, BU946493, BX514270
      Consensus CDS
      CCDS48583.1
      UniProtKB/TrEMBL
      D3Z3N4
      Related
      ENSMUSP00000020263.8, ENSMUST00000020263.14
      Conserved Domains (2) summary
      cd12735
      Location:195 → 269
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    2. NM_001347457.1 → NP_001334386.1  heterogeneous nuclear ribonucleoprotein H3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AC113107, AI666703, BQ443117, BX514270
      Consensus CDS
      CCDS83704.1
      UniProtKB/TrEMBL
      D3YWT1
      Conserved Domains (2) summary
      cd12735
      Location:180 → 254
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    3. NM_001359260.1 → NP_001346189.1  heterogeneous nuclear ribonucleoprotein H3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AA444345, AC113107, AI666703, BQ443117
      Consensus CDS
      CCDS48583.1
      UniProtKB/TrEMBL
      D3Z3N4
      Conserved Domains (2) summary
      cd12735
      Location:195 → 269
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    4. NM_001359261.1 → NP_001346190.1  heterogeneous nuclear ribonucleoprotein H3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113107, AI666703, BM948718, BQ443117, BX514270
      Conserved Domains (1) summary
      cl17169
      Location:64 → 138
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      62850443..62859764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513839.5 → XP_006513902.1  heterogeneous nuclear ribonucleoprotein H3 isoform X2

      See identical proteins and their annotated locations for XP_006513902.1

      UniProtKB/TrEMBL
      D3YWT1
      Related
      ENSMUSP00000112424.2, ENSMUST00000118898.8
      Conserved Domains (2) summary
      cd12735
      Location:180 → 254
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    2. XM_030245163.1 → XP_030101023.1  heterogeneous nuclear ribonucleoprotein H3 isoform X3

      Conserved Domains (1) summary
      cl17169
      Location:64 → 138
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_030245166.1 → XP_030101026.1  heterogeneous nuclear ribonucleoprotein H3 isoform X4

      Conserved Domains (1) summary
      cl17169
      Location:44 → 106
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_006513837.4 → XP_006513900.1  heterogeneous nuclear ribonucleoprotein H3 isoform X1

      See identical proteins and their annotated locations for XP_006513900.1

      UniProtKB/TrEMBL
      D3Z3N4
      Conserved Domains (2) summary
      cd12735
      Location:195 → 269
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    5. XM_030245159.2 → XP_030101019.1  heterogeneous nuclear ribonucleoprotein H3 isoform X2

      UniProtKB/TrEMBL
      D3YWT1
      Conserved Domains (2) summary
      cd12735
      Location:180 → 254
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    6. XM_030245164.1 → XP_030101024.1  heterogeneous nuclear ribonucleoprotein H3 isoform X3

      Conserved Domains (1) summary
      cl17169
      Location:64 → 138
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. XM_030245168.2 → XP_030101028.1  heterogeneous nuclear ribonucleoprotein H3 isoform X5

      Conserved Domains (1) summary
      cl17169
      Location:26 → 100
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. XM_030245167.2 → XP_030101027.1  heterogeneous nuclear ribonucleoprotein H3 isoform X5

      Conserved Domains (1) summary
      cl17169
      Location:26 → 100
      RRM_SF; RNA recognition motif (RRM) superfamily

    9. XM_030245170.1 → XP_030101030.1  heterogeneous nuclear ribonucleoprotein H3 isoform X5

      Conserved Domains (1) summary
      cl17169
      Location:26 → 100
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. XM_030245165.1 → XP_030101025.1  heterogeneous nuclear ribonucleoprotein H3 isoform X3

      Conserved Domains (1) summary
      cl17169
      Location:64 → 138
      RRM_SF; RNA recognition motif (RRM) superfamily

    11. XM_030245158.1 → XP_030101018.1  heterogeneous nuclear ribonucleoprotein H3 isoform X1

      UniProtKB/TrEMBL
      D3Z3N4
      Conserved Domains (2) summary
      cd12735
      Location:195 → 269
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    12. XM_030245160.1 → XP_030101020.1  heterogeneous nuclear ribonucleoprotein H3 isoform X2

      UniProtKB/TrEMBL
      D3YWT1
      Conserved Domains (2) summary
      cd12735
      Location:180 → 254
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    13. XM_030245161.1 → XP_030101021.1  heterogeneous nuclear ribonucleoprotein H3 isoform X2

      UniProtKB/TrEMBL
      D3YWT1
      Conserved Domains (2) summary
      cd12735
      Location:180 → 254
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    14. XM_030245162.1 → XP_030101022.1  heterogeneous nuclear ribonucleoprotein H3 isoform X3

      Conserved Domains (1) summary
      cl17169
      Location:64 → 138
      RRM_SF; RNA recognition motif (RRM) superfamily

    15. XM_030245169.1 → XP_030101029.1  heterogeneous nuclear ribonucleoprotein H3 isoform X5

      Conserved Domains (1) summary
      cl17169
      Location:26 → 100
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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