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    Vstm2l V-set and transmembrane domain containing 2-like [ Mus musculus (house mouse) ]

    Gene ID: 277432, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Vstm2lprovided by MGI
    Official Full Name
    V-set and transmembrane domain containing 2-likeprovided by MGI
    Primary source
    MGI:MGI:2685537
    See related
    Ensembl:ENSMUSG00000037843 AllianceGenome:MGI:2685537
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm691
    Summary
    Involved in negative regulation of neuron apoptotic process. Located in extracellular region. Orthologous to human VSTM2L (V-set and transmembrane domain containing 2 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 27.6), CNS E14 (RPKM 27.4) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vstm2l in Genome Data Viewer
    Location:
    2 H1; 2 78.48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157756573..157786639)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157914653..157944719)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2055 Neighboring gene catenin, beta like 1 Neighboring gene STARR-seq mESC enhancer starr_06218 Neighboring gene STARR-seq mESC enhancer starr_06220 Neighboring gene STARR-seq mESC enhancer starr_06222 Neighboring gene ubiquitin-conjugating enzyme E2I pseudogene Neighboring gene predicted gene, 34402 Neighboring gene TELO2 interacting protein 1 Neighboring gene mediator of cell motility 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin. Rossini L, et al. FASEB J, 2011 Jun. PMID 21393573
    2. Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. Zhang Q, et al. Cell Death Dis, 2018 Feb 14. PMID 29445148, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC67359

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    V-set and transmembrane domain-containing protein 2-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198627.2 → NP_941029.2  V-set and transmembrane domain-containing protein 2-like protein precursor

      See identical proteins and their annotated locations for NP_941029.2

      Status: VALIDATED

      Source sequence(s)
      BC058538, BF323097, BQ746346
      Consensus CDS
      CCDS50784.1
      UniProtKB/TrEMBL
      A2ACD2
      Related
      ENSMUSP00000105149.2, ENSMUST00000109523.2
      Conserved Domains (2) summary
      pfam13927
      Location:43 → 144
      Ig_3; Immunoglobulin domain
      cd00096
      Location:50 → 52
      Ig; Ig strand A' [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      157756573..157786639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PDS0.1 GenPept UniProtKB/Swiss-Prot:Q6PDS0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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