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    Kcns3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 238076, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kcns3provided by MGI
    Official Full Name
    potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3provided by MGI
    Primary source
    MGI:MGI:1098804
    See related
    Ensembl:ENSMUSG00000043673 AllianceGenome:MGI:1098804
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in dentate gyrus subgranular zone. Orthologous to human KCNS3 (potassium voltage-gated channel modifier subfamily S member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 2.9), genital fat pad adult (RPKM 2.7) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcns3 in Genome Data Viewer
    Location:
    12 A1.1; 12 5.58 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (11140738..11201186, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (11090202..11151168, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene phosphoglycerate kinase-1, related sequence-7 Neighboring gene RIKEN cDNA 7420701I03 gene Neighboring gene STARR-seq mESC enhancer starr_31535 Neighboring gene STARR-seq mESC enhancer starr_31536 Neighboring gene RIKEN cDNA 9530020I12 gene Neighboring gene STARR-seq mESC enhancer starr_31537 Neighboring gene STARR-seq mESC enhancer starr_31538 Neighboring gene mesogenin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Kcns3 deficiency disrupts Parvalbumin neuron physiology in mouse prefrontal cortex: Implications for the pathophysiology of schizophrenia. Miyamae T, et al. Neurobiol Dis, 2021 Jul. PMID 33940180, Free PMC Article
    2. Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity. Shrestha BR, et al. Cell, 2018 Aug 23. PMID 30078709, Free PMC Article
    3. Fine mapping of Ath6, a quantitative trait locus for atherosclerosis in mice. Purcell MK, et al. Mamm Genome, 2001 Jul. PMID 11420610
    4. Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Kaiser M, et al. Development, 2021 Apr 15. PMID 33795231
    5. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Harrell MD, et al. Physiol Genomics, 2007 Feb 12. PMID 16985003

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kcns3 deficiency disrupts Parvalbumin neuron physiology in mouse prefrontal cortex: Implications for the pathophysiology of schizophrenia.
      Title: Kcns3 deficiency disrupts Parvalbumin neuron physiology in mouse prefrontal cortex: Implications for the pathophysiology of schizophrenia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • D12Ertd137e

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily S member 3
    Names
    voltage-gated potassium channel subunit Kv9.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168564.2 → NP_001162036.1  potassium voltage-gated channel subfamily S member 3

      See identical proteins and their annotated locations for NP_001162036.1

      Status: VALIDATED

      Source sequence(s)
      AC120406
      Consensus CDS
      CCDS25813.1
      UniProtKB/Swiss-Prot
      Q8BQZ8
      Related
      ENSMUSP00000129412.2, ENSMUST00000164495.9
      Conserved Domains (2) summary
      cd18428
      Location:15 → 122
      BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
      pfam00520
      Location:184 → 417
      Ion_trans; Ion transport protein

    2. NM_001413254.1 → NP_001400183.1  potassium voltage-gated channel subfamily S member 3

      Status: VALIDATED

      Source sequence(s)
      AC120406
      UniProtKB/Swiss-Prot
      Q8BQZ8

    3. NM_001413255.1 → NP_001400184.1  potassium voltage-gated channel subfamily S member 3

      Status: VALIDATED

      Source sequence(s)
      AC120406
      UniProtKB/Swiss-Prot
      Q8BQZ8

    4. NM_001413256.1 → NP_001400185.1  potassium voltage-gated channel subfamily S member 3

      Status: VALIDATED

      Source sequence(s)
      AC120406
      UniProtKB/Swiss-Prot
      Q8BQZ8
      Related
      ENSMUSP00000152026.2, ENSMUST00000217974.2

    5. NM_001413257.1 → NP_001400186.1  potassium voltage-gated channel subfamily S member 3

      Status: VALIDATED

      Source sequence(s)
      AC120406
      UniProtKB/Swiss-Prot
      Q8BQZ8

    6. NM_001413258.1 → NP_001400187.1  potassium voltage-gated channel subfamily S member 3

      Status: VALIDATED

      Source sequence(s)
      AC120406
      UniProtKB/Swiss-Prot
      Q8BQZ8

    7. NM_001413259.1 → NP_001400188.1  potassium voltage-gated channel subfamily S member 3

      Status: VALIDATED

      Source sequence(s)
      AC120406
      UniProtKB/Swiss-Prot
      Q8BQZ8

    8. NM_173417.4 → NP_775593.1  potassium voltage-gated channel subfamily S member 3

      See identical proteins and their annotated locations for NP_775593.1

      Status: VALIDATED

      Source sequence(s)
      AC120406
      Consensus CDS
      CCDS25813.1
      UniProtKB/Swiss-Prot
      Q8BQZ8
      Related
      ENSMUSP00000060706.2, ENSMUST00000055673.2
      Conserved Domains (2) summary
      cd18428
      Location:15 → 122
      BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
      pfam00520
      Location:184 → 417
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      11140738..11201186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243867.1 → XP_011242169.1  potassium voltage-gated channel subfamily S member 3 isoform X2

      See identical proteins and their annotated locations for XP_011242169.1

      Conserved Domains (2) summary
      cl38908
      Location:4 → 40
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:102 → 335
      Ion_trans; Ion transport protein

    2. XM_011243866.3 → XP_011242168.1  potassium voltage-gated channel subfamily S member 3 isoform X1

      See identical proteins and their annotated locations for XP_011242168.1

      UniProtKB/Swiss-Prot
      Q8BQZ8
      Conserved Domains (2) summary
      cd18428
      Location:15 → 122
      BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
      pfam00520
      Location:184 → 417
      Ion_trans; Ion transport protein

    3. XM_006515080.4 → XP_006515143.1  potassium voltage-gated channel subfamily S member 3 isoform X1

      See identical proteins and their annotated locations for XP_006515143.1

      UniProtKB/Swiss-Prot
      Q8BQZ8
      Conserved Domains (2) summary
      cd18428
      Location:15 → 122
      BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
      pfam00520
      Location:184 → 417
      Ion_trans; Ion transport protein

    4. XM_006515082.4 → XP_006515145.1  potassium voltage-gated channel subfamily S member 3 isoform X2

      See identical proteins and their annotated locations for XP_006515145.1

      Conserved Domains (2) summary
      cl38908
      Location:4 → 40
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:102 → 335
      Ion_trans; Ion transport protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQZ8.1 GenPept UniProtKB/Swiss-Prot:Q8BQZ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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