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    H60c histocompatibility 60c [ Mus musculus (house mouse) ]

    Gene ID: 670558, updated on 27-Nov-2024

    Summary

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    Official Symbol
    H60cprovided by MGI
    Official Full Name
    histocompatibility 60cprovided by MGI
    Primary source
    MGI:MGI:3774845
    See related
    Ensembl:ENSMUSG00000091618 AllianceGenome:MGI:3774845
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm9491; 4632413I24Rik
    Summary
    Enables natural killer cell lectin-like receptor binding activity. Acts upstream of or within natural killer cell mediated cytotoxicity. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 2.8), limb E14.5 (RPKM 0.8) and 5 other tissues See more
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    Genomic context

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    See H60c in Genome Data Viewer
    Location:
    10 A1; 10 2.08 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (3206202..3218091, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (3256202..3268091, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25677 Neighboring gene predicted gene, 51789 Neighboring gene predicted gene 6667 Neighboring gene predicted gene, 29826 Neighboring gene ribosomal protein L35a pseudogene Neighboring gene STARR-seq mESC enhancer starr_25675 Neighboring gene ring finger and WD repeat domain 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair. Yoshida S, et al. J Immunol, 2012 Apr 15. PMID 22403443
    2. Gut microbiota regulates NKG2D ligand expression on intestinal epithelial cells. Hansen CH, et al. Eur J Immunol, 2013 Feb. PMID 23136011
    3. Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D. Takada A, et al. J Immunol, 2008 Feb 1. PMID 18209064
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a more general role for H60c in the maintenance of epithelial integrity.
      Title: Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair.
    2. Identified two novel mouse chromosome 10-encoded NKG2D ligands, H60b and H60c, structurally resembling H60.
      Title: Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables natural killer cell lectin-like receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within natural killer cell mediated cytotoxicity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histocompatibility antigen 60c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204916.2 → NP_001191845.1  histocompatibility antigen 60c precursor

      See identical proteins and their annotated locations for NP_001191845.1

      Status: VALIDATED

      Source sequence(s)
      AB284506, AC157021, AK014573
      Consensus CDS
      CCDS56668.1
      UniProtKB/Swiss-Prot
      B1B213
      UniProtKB/TrEMBL
      A0A1L1SRI2
      Related
      ENSMUSP00000126536.3, ENSMUST00000170893.3
      Conserved Domains (1) summary
      cl08246
      Location:16 → 133
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      3206202..3218091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245226.1 → XP_030101086.1  histocompatibility antigen 60c isoform X3

      Conserved Domains (1) summary
      cl08246
      Location:99 → 216
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    2. XM_030245225.1 → XP_030101085.1  histocompatibility antigen 60c isoform X2

      UniProtKB/TrEMBL
      A0A1L1SRI2
      Related
      ENSMUSP00000149470.2, ENSMUST00000216211.2
      Conserved Domains (1) summary
      cl08246
      Location:98 → 215
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    3. XM_006512485.4 → XP_006512548.1  histocompatibility antigen 60c isoform X1

      UniProtKB/TrEMBL
      A0A1L1SRI2
      Conserved Domains (1) summary
      cl08246
      Location:99 → 216
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1B213.1 GenPept UniProtKB/Swiss-Prot:B1B213

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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