Tacr1 tachykinin receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tacr1provided by RGD
Official Full Name: tachykinin receptor 1provided by RGD
Primary source: RGD:3811
See related: EnsemblRapid:ENSRNOG00000005853 AllianceGenome:RGD:3811
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tac1r
Summary: Enables substance P receptor activity. Involved in several processes, including learning or memory; positive regulation of cell communication; and regulation of cell migration. Located in cell body; cell surface; and dendrite. Is active in postsynaptic membrane. Used to study central sleep apnea; cystitis; pancreatitis; and pulmonary hypertension. Biomarker of acute necrotizing pancreatitis; allergic rhinitis; asthma; colitis; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in developmental disorder of mental health and exercise-induced bronchoconstriction. Orthologous to human TACR1 (tachykinin receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 7.7), Brain (RPKM 7.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (116478617..116647492)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (114920844..115089733)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (113247236..113416139)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of NK1R attenuates LPS-induced microglial inflammation and consequent death of PC12 cells.
Title: Inhibition of NK1R attenuates LPS-induced microglial inflammation and consequent death of PC12 cells.
Neurokinin 1 receptor activation in the rat spinal cord maintains latent sensitization, a model of inflammatory and neuropathic chronic pain.
Title: Neurokinin 1 receptor activation in the rat spinal cord maintains latent sensitization, a model of inflammatory and neuropathic chronic pain.
Regulation of Cardiac Mast Cell Maturation and Function by the Neurokinin-1 Receptor in the Fibrotic Heart.
Title: Regulation of Cardiac Mast Cell Maturation and Function by the Neurokinin-1 Receptor in the Fibrotic Heart.
Substance P participates in periodontitis by upregulating HIF-1alpha and RANKL/OPG ratio.
Title: Substance P participates in periodontitis by upregulating HIF-1α and RANKL/OPG ratio.
These data suggest that, through the substance P (SP) receptor, SP could play an important role in regulating postnatal developmental.
Title: Substance P receptor in the rat indusium griseum during postnatal development.
These findings reported here for the first time suggest an important role for a SP/NK1R system, either as genetic and/or epigenetic factor, in both the cytoplasm and nucleus functions of the adipose stem cells.
Title: Immunolocalization of Substance P and NK-1 Receptor in ADIPOSE Stem Cells.
Neurokinin-1 receptor-expressing neurons in rostro ventromedial medulla appear essential for the development but contribute only partially to the maintenance of chronic post-thoracotomy pain.
Title: A role for neurokinin-1 receptor neurons in the rostral ventromedial medulla in the development of chronic postthoracotomy pain.
These results reveal a critical role for endosomal signaling of the NK1R in the complex pathophysiology of pain.
Title: Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.
Substance P microinjections produced antinociceptive effects only in the Medial Amygdala through NK-1 receptor activation. No USV emissions were detected after the SP microinjections.
Title: Inhibition of substance P-induced defensive behavior via neurokinin-1 receptor antagonism in the central and medial but not basolateral nuclei of the amygdala in male Wistar rats.
UVB irradiation induced a significant reduction of the proportion of galanin positive DRG neurons for all time points, except at 12h.UVB irradiation induced increased substance P immunoreactivity in the dorsal part of the spinal cord 48h after irradiation. UVB irradiation also induced c-fos immunoreactivity in the dorsal horn and the area around the central canal 24 and 48h after exposure
Title: UVB irradiation induces rapid changes in galanin, substance P and c-fos immunoreactivity in rat dorsal root ganglia and spinal cord.

Submit: New GeneRIF Correction See all GeneRIFs (131)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:480302 (e-PCR)
- UniSTS:480302

Tacr1 (e-PCR), detects polymorphism
- UniSTS:480302

D4MGH17 (e-PCR)
- UniSTS:121920

AU026738 (e-PCR)
- UniSTS:113985

D4Wox19 (e-PCR)
- UniSTS:239480

Tacr1 (e-PCR), detects polymorphism
- UniSTS:507268

D4Arb39 (e-PCR)
- UniSTS:240024

RH138512 (e-PCR)
- UniSTS:220599

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables substance P receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables substance P receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables substance P receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiotensin-mediated drinking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in operant conditioning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lymphocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of uterine smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of uterine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in response to auditory stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hormone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nicotine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ozone	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to pain	ISO Inferred from Sequence Orthology more info
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in smooth muscle contraction involved in micturition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm ejaculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tachykinin receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm head	ISO Inferred from Sequence Orthology more info
is_active_in sperm midpiece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: substance-P receptor

Names: NK-1 receptor; NK-1R; SPR; neurokinin 1 receptor; substance p receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.