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    Mapkapk2 MAPK activated protein kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289014, updated on 3-Dec-2024

    Summary

    Official Symbol
    Mapkapk2provided by RGD
    Official Full Name
    MAPK activated protein kinase 2provided by RGD
    Primary source
    RGD:631362
    See related
    EnsemblRapid:ENSRNOG00000004726 AllianceGenome:RGD:631362
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including macropinocytosis; peptidyl-serine phosphorylation; and regulation of gene expression. Predicted to act upstream of or within inner ear development; p38MAPK cascade; and positive regulation of gene expression. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 849.3), Muscle (RPKM 590.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mapkapk2 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (45066027..45112326, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (42513762..42560061, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (47785157..47871684, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glycine (anticodon UCC) 11 Neighboring gene interleukin 19 Neighboring gene interleukin 10 Neighboring gene uncharacterized LOC134481555 Neighboring gene uncharacterized LOC134481556 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 3 Neighboring gene eukaryotic translation initiation factor 2D

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to vascular endothelial growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inner ear development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in macropinocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of macrophage cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cytokine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    MAP kinase-activated protein kinase 2
    Names
    mitogen-activated protein kinase-activated protein kinase 2
    NP_835203.1
    XP_063128136.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178102.2NP_835203.1  MAP kinase-activated protein kinase 2

      See identical proteins and their annotated locations for NP_835203.1

      Status: PROVISIONAL

      Source sequence(s)
      AY197741
      UniProtKB/TrEMBL
      A0A8I5Y100, F1M9C0, Q80ZF4
      Related
      ENSRNOP00000076947.1, ENSRNOT00000100098.2
      Conserved Domains (2) summary
      smart00220
      Location:54311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14170
      Location:47349
      STKc_MAPKAPK2; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      45066027..45112326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272066.1XP_063128136.1  MAP kinase-activated protein kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZC5