Fads3 fatty acid desaturase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fads3provided by RGD
Official Full Name: fatty acid desaturase 3provided by RGD
Primary source: RGD:628876
See related: EnsemblRapid:ENSRNOG00000020385 AllianceGenome:RGD:628876
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. Predicted to be involved in lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human FADS3 (fatty acid desaturase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 299.8), Heart (RPKM 185.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (216110547..216127431)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (206685667..206702538)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (226091774..226108332)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

physiological evidence demonstrates the existence of in vivo synthesis of trans11,cis13-CLA from dietary trans-vaccenic acid in rodents; and establishes the FADS3 enzyme as a reliable mammalian trans-vaccenate Delta13-desaturase in vivo.
Title: Conversion of dietary trans-vaccenic acid to trans11,cis13-conjugated linoleic acid in the rat lactating mammary gland by Fatty Acid Desaturase 3-catalyzed methyl-end Δ13-desaturation.
FADS3 was secreted specifically by hepatocytes in the extracellular matrix where it was located on fibronectin-containing fibers.The 51 kDa FADS3 is secreted in the extracellular matrix of hepatocytes and blood.
Title: The 51 kDa FADS3 is secreted in the ECM of hepatocytes and blood in rat.
FADS3 is the first "methyl-end" fatty acid desaturase functionally characterized in mammals
Title: Trans-vaccenate is Δ13-desaturated by FADS3 in rodents.
FADS3 does exist under multiple protein isoforms depending on the mammalian tissues.
Title: The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in unsaturated fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within unsaturated fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fatty acid desaturase 3

Names: delta(13) desaturase; delta(13) fatty acid desaturase; putative fatty acid desaturase; trans-vaccenate Delta13-desaturase

NP_775160.1

EC 1.14.19.-

XP_038958618.1

EC 1.14.19.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173137.1 → NP_775160.1 fatty acid desaturase 3

See identical proteins and their annotated locations for NP_775160.1

Status: PROVISIONAL

Source sequence(s)

AJ494720

UniProtKB/Swiss-Prot

Q8K1P9

UniProtKB/TrEMBL

A0A8L2QF31, R4HD46

Related

ENSRNOP00000099327.1, ENSRNOT00000123308.1

Conserved Domains (2) summary

PLN03199
Location:27 → 444

PLN03199; delta6-acyl-lipid desaturase-like protein; Provisional

cd03506
Location:168 → 417

Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

216110547..216127431

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102690.2 → XP_038958618.1 fatty acid desaturase 3 isoform X1

Conserved Domains (1) summary

PLN03199
Location:122 → 340

PLN03199; delta6-acyl-lipid desaturase-like protein; Provisional