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    Tor1aip2 torsin 1A interacting protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304881, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tor1aip2provided by RGD
    Official Full Name
    torsin 1A interacting protein 2provided by RGD
    Primary source
    RGD:735059
    See related
    EnsemblRapid:ENSRNOG00000024849 EnsemblRapid:ENSRNOG00000048267 AllianceGenome:RGD:735059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATPase activator activity and ATPase binding activity. Predicted to be involved in several processes, including endoplasmic reticulum organization; positive regulation of ATP-dependent activity; and protein localization to nuclear envelope. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be active in endoplasmic reticulum and membrane. Orthologous to human TOR1AIP2 (torsin 1A interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 206.9), Liver (RPKM 192.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tor1aip2 in Genome Data Viewer
    Location:
    13q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (70775483..70806794)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (68225226..68256536)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (73704088..73735339)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096287 Neighboring gene centrosomal protein 350 Neighboring gene interferon induced transmembrane protein 2, pseudogene 2 Neighboring gene torsin 1A interacting protein 1 Neighboring gene family with sequence similarity 163, member A Neighboring gene uncharacterized LOC120096289 Neighboring gene ATP synthase F1 subunit gamma, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LULL1 retargets TorsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutation. Vander Heyden AB, et al. Mol Biol Cell, 2009 Jun. PMID 19339278, Free PMC Article
    2. Arresting a Torsin ATPase reshapes the endoplasmic reticulum. Rose AE, et al. J Biol Chem, 2014 Jan 3. PMID 24275647, Free PMC Article
    3. The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein. Goodchild RE, et al. J Cell Biol, 2005 Mar 14. PMID 15767459, Free PMC Article
    4. Regulation of Torsin ATPases by LAP1 and LULL1. Zhao C, et al. Proc Natl Acad Sci U S A, 2013 Apr 23. PMID 23569223, Free PMC Article
    5. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72610

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ATP-dependent activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    torsin-1A-interacting protein 2; interferon alpha responsive protein
    Names
    torsin A interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165896.1 → NP_001159368.1  interferon alpha responsive protein isoform a

      See identical proteins and their annotated locations for NP_001159368.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) shares a portion of its 5' UTR, but no coding sequence with variant 1. Variant 2 encodes a shorter protein (interferon alpha responsive protein), which is distinct from torsin-1A-interacting protein 2. Variants 2 and 3 encode the same protein, isoform a.
      Source sequence(s)
      CB804669, CO565924, CV107022, DV728294, EV767100
      UniProtKB/TrEMBL
      M0R5U6
      Related
      ENSRNOP00000071656.1, ENSRNOT00000077874.3

    2. NM_001165897.1 → NP_001159369.1  interferon alpha responsive protein isoform a

      See identical proteins and their annotated locations for NP_001159369.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) shares a portion of its 5' UTR, but no coding sequence with variant 1. Variant 3 encodes a shorter protein, (interferon alpha responsive protein), which is distinct from torsin-1A-interacting protein 2. Variants 2 and 3 encode the same protein, isoform a.
      Source sequence(s)
      CB804669, CK478392, CO565924, DV728294, EV767100
      UniProtKB/TrEMBL
      M0R5U6
      Related
      ENSRNOP00000084434.1, ENSRNOT00000104928.2

    3. NM_199100.4 → NP_954531.1  torsin-1A-interacting protein 2 isoform b

      See identical proteins and their annotated locations for NP_954531.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein, isoform b, referred to as torsin-1A-interacting protein 2.
      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q6P752
      UniProtKB/TrEMBL
      A0A8I6AJQ9
      Conserved Domains (1) summary
      pfam05609
      Location:28 → 568
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      70775483..70806794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250045.5 → XP_006250107.1  torsin-1A-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006250107.1

      UniProtKB/Swiss-Prot
      Q6P752
      UniProtKB/TrEMBL
      A0A8I6AJQ9
      Conserved Domains (1) summary
      pfam05609
      Location:28 → 568
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)

    2. XM_039090736.2 → XP_038946664.1  torsin-1A-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6P752
      UniProtKB/TrEMBL
      A0A8I6AJQ9
      Conserved Domains (1) summary
      pfam05609
      Location:28 → 568
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)

    3. XM_039090735.2 → XP_038946663.1  torsin-1A-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6P752
      UniProtKB/TrEMBL
      A0A8I6AJQ9
      Related
      ENSRNOP00000039176.3, ENSRNOT00000050734.6
      Conserved Domains (1) summary
      pfam05609
      Location:28 → 568
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)

    4. XM_006250043.5 → XP_006250105.1  torsin-1A-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006250105.1

      UniProtKB/Swiss-Prot
      Q6P752
      UniProtKB/TrEMBL
      A0A8I6AJQ9
      Conserved Domains (1) summary
      pfam05609
      Location:28 → 568
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P752.1 GenPept UniProtKB/Swiss-Prot:Q6P752

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