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    Srgap2 SLIT-ROBO Rho GTPase activating protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360840, updated on 3-Dec-2024

    Summary

    Official Symbol
    Srgap2provided by RGD
    Official Full Name
    SLIT-ROBO Rho GTPase activating protein 2provided by RGD
    Primary source
    RGD:1566016
    See related
    EnsemblRapid:ENSRNOG00000006733 AllianceGenome:RGD:1566016
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566016
    Summary
    Predicted to enable GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Predicted to be involved in several processes, including plasma membrane bounded cell projection organization; substrate adhesion-dependent cell spreading; and synapse assembly. Located in cytoplasm and nucleus. Orthologous to several human genes including SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 73.9), Brain (RPKM 70.7) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Srgap2 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (45298192..45519330, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (42745956..42967091, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (48065280..48286888, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene Ras association domain family member 5 Neighboring gene uncharacterized LOC134481557 Neighboring gene inhibitor of nuclear factor kappa B kinase subunit epsilon Neighboring gene uncharacterized LOC120096246 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 pseudogene Neighboring gene family with sequence similarity 72, member A Neighboring gene uncharacterized LOC134481491 Neighboring gene uncharacterized LOC134481492

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC188551

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament severing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament severing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in excitatory synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inhibitory synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lamellipodium assembly involved in ameboidal cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine head ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine head ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    SLIT-ROBO Rho GTPase-activating protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134958.1NP_001128430.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001128430.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168690
      UniProtKB/TrEMBL
      A0A8I5ZL53, B5DEJ1
      Related
      ENSRNOP00000008976.5, ENSRNOT00000008976.7
      Conserved Domains (3) summary
      cd11955
      Location:732784
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:487674
      RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
      cl12013
      Location:26289
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_001401376.1NP_001388305.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      D4A208
      UniProtKB/TrEMBL
      A0A8I5ZL53
      Related
      ENSRNOP00000068925.1, ENSRNOT00000085967.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      45298192..45519330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090884.2XP_038946812.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZL53
      Conserved Domains (4) summary
      cd07682
      Location:26288
      F-BAR_srGAP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 2
      PHA03269
      Location:9621064
      PHA03269; envelope glycoprotein C; Provisional
      cd11955
      Location:731783
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:486673
      RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
    2. XM_006249783.5XP_006249845.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006249845.1

      UniProtKB/Swiss-Prot
      D4A208
      UniProtKB/TrEMBL
      A0A8I5ZL53
      Conserved Domains (3) summary
      cd07682
      Location:26289
      F-BAR_srGAP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 2
      cd11955
      Location:732784
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:487674
      RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    3. XM_006249785.4XP_006249847.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZL53
      Related
      ENSRNOP00000070956.2, ENSRNOT00000086928.3
      Conserved Domains (3) summary
      cd11955
      Location:666718
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:421608
      RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
      cl12013
      Location:21223
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    4. XM_039090887.1XP_038946815.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZL53
      Conserved Domains (4) summary
      PHA03269
      Location:810912
      PHA03269; envelope glycoprotein C; Provisional
      cd11955
      Location:579631
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:334521
      RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
      cl12013
      Location:1136
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    5. XM_039090885.2XP_038946813.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JZ92, A0A8I5ZL53
      Related
      ENSRNOP00000112019.1, ENSRNOT00000127076.1
      Conserved Domains (3) summary
      cd11955
      Location:732784
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:487674
      RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
      cl12013
      Location:26289
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    6. XM_039090886.2XP_038946814.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZL53
      Conserved Domains (3) summary
      cd11955
      Location:732784
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:487674
      RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
      cl12013
      Location:26289
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    7. XM_039090888.2XP_038946816.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZL53
      Conserved Domains (3) summary
      cd11955
      Location:732784
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:487674
      RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
      cl12013
      Location:26289
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature