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    Styxl1 serine/threonine/tyrosine interacting-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360792, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Styxl1provided by RGD
    Official Full Name
    serine/threonine/tyrosine interacting-like 1provided by RGD
    Primary source
    RGD:1305845
    See related
    EnsemblRapid:ENSRNOG00000023366 AllianceGenome:RGD:1305845
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dusp24; RGD1305845
    Summary
    Predicted to enable protein phosphatase binding activity; protein phosphatase inhibitor activity; and pseudophosphatase activity. Predicted to be involved in negative regulation of stress granule assembly; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of neuron projection development. Predicted to be active in mitochondrion. Orthologous to human STYXL1 (serine/threonine/tyrosine interacting like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 41.2), Adrenal (RPKM 25.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Styxl1 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26544059..26576365)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (20907410..20940232)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (23954563..23987155)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix 3 Neighboring gene uncharacterized LOC108352435 Neighboring gene malate dehydrogenase 2 Neighboring gene transmembrane protein 120A Neighboring gene cytochrome p450 oxidoreductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The pseudophosphatase MK-STYX induces neurite-like outgrowths in PC12 cells. Flowers BM, et al. PLoS One, 2014. PMID 25479605, Free PMC Article
    2. MK-STYX Alters the Morphology of Primary Neurons, and Outgrowths in MK-STYX Overexpressing PC-12 Cells Develop a Neuronal Phenotype. Banks DA, et al. Front Mol Biosci, 2017. PMID 29250526, Free PMC Article
    3. The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1. Niemi NM, et al. PLoS One, 2014. PMID 24709986, Free PMC Article
    4. The pseudophosphatase MK-STYX inhibits stress granule assembly independently of Ser149 phosphorylation of G3BP-1. Barr JE, et al. FEBS J, 2013 Jan. PMID 23163895, Free PMC Article
    5. The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation. Hinton SD, et al. Biochem J, 2010 Apr 14. PMID 20180778, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC112640

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudophosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudophosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of stress granule assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine/tyrosine-interacting-like protein 1
    Names
    map kinase phosphatase-like protein MK-STYX

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037788.2 → NP_001032877.2  serine/threonine/tyrosine-interacting-like protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J0B4, G3V9J5, Q4G076
      Related
      ENSRNOP00000049678.3, ENSRNOT00000046343.6
      Conserved Domains (2) summary
      cl00125
      Location:33 → 146
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
      cl28904
      Location:158 → 311
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      26544059..26576365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271486.1 → XP_063127556.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A6J0B4, G3V9J5, Q4G076

    2. XM_063271485.1 → XP_063127555.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A6J0B4, G3V9J5, Q4G076

    3. XM_006249181.5 → XP_006249243.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006249243.1

      UniProtKB/TrEMBL
      A6J0B4, G3V9J5, Q4G076
      Conserved Domains (2) summary
      cl00125
      Location:33 → 146
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
      cl28904
      Location:158 → 311
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. XM_063271489.1 → XP_063127559.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X4

    5. XM_063271487.1 → XP_063127557.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4G076

    6. XM_063271491.1 → XP_063127561.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

      UniProtKB/TrEMBL
      A6J0B5

    7. XM_063271484.1 → XP_063127554.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A6J0B4, G3V9J5, Q4G076

    8. XM_063271490.1 → XP_063127560.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X4

    9. XM_063271492.1 → XP_063127562.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

      UniProtKB/TrEMBL
      A6J0B5

    10. XM_063271488.1 → XP_063127558.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X3

      UniProtKB/TrEMBL
      Q4G076
    Nucleotide Protein Strain
    Heading Accession and Version

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