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    aprE serine alkaline protease (Ca(2+)-dependent subtilisin E) [ Bacillus subtilis subsp. subtilis str. 168 ]

    Gene ID: 939313, updated on 6-Oct-2023

    Summary

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    Gene symbol
    aprE
    Gene description
    serine alkaline protease (Ca(2+)-dependent subtilisin E)
    Locus tag
    BSU_10300
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
    Lineage
    Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
    Old locus tag
    BSU10300
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    Genomic context

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    Sequence:
    NC_000964.3 (1104423..1105568, complement)

    NC_000964.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene putative membrane metalloprotease Neighboring gene putative N-acetyltransferase Neighboring gene putative oxidoreductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000964.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Formation of the high-affinity calcium binding site in pro-subtilisin E with the insertion sequence IS1 of pro-Tk-subtilisin. Uehara R, et al. Biochemistry, 2013 Dec 17. PMID 24279884
    2. Bacillus subtilis SalA is a phosphorylation-dependent transcription regulator that represses scoC and activates the production of the exoprotease AprE. Derouiche A, et al. Mol Microbiol, 2015 Sep. PMID 26094643
    3. Mutational analysis of the helix-turn-helix region of Bacillus subtilis response regulator DegU, and identification of cis-acting sequences for DegU in the aprE and comK promoters. Shimane K, et al. J Biochem, 2004 Sep. PMID 15598897
    4. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
    5. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A mutant mimicking phosphorylation of SalA (SalA Y327E) exhibited a strong repression of scoC and consequently overproduction of AprE.
      Title: Bacillus subtilis SalA is a phosphorylation-dependent transcription regulator that represses scoC and activates the production of the exoprotease AprE.
    2. The results suggest that IS1 facilitates the formation of the Ca1 site and the complete folding of Pro-subtilisin E and thereby accelerates its autoprocessing.
      Title: Formation of the high-affinity calcium binding site in pro-subtilisin E with the insertion sequence IS1 of pro-Tk-subtilisin.
    3. DegU functions through the inverted repeat in the comK promoter and the tandem repeat in the aprE promoter
      Title: Mutational analysis of the helix-turn-helix region of Bacillus subtilis response regulator DegU, and identification of cis-acting sequences for DegU in the aprE and comK promoters.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    serine alkaline protease (Ca(2+)-dependent subtilisin E)
    NP_388911.2
    • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000964.3 Reference assembly

      Range
      1104423..1105568 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_388911.2 serine alkaline protease (Ca(2+)-dependent subtilisin E) [Bacillus subtilis subsp. subtilis str. 168]

      See identical proteins and their annotated locations for NP_388911.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1L2BPI2
      Conserved Domains (2) summary
      cd07477
      Location:131 → 359
      Peptidases_S8_Subtilisin_subset; Peptidase S8 family domain in Subtilisin proteins
      pfam05922
      Location:38 → 102
      Inhibitor_I9; Peptidase inhibitor I9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04189.3

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    Research Materials