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    Mfap1a microfibrillar-associated protein 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499878, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mfap1aprovided by RGD
    Official Full Name
    microfibrillar-associated protein 1Aprovided by RGD
    Primary source
    RGD:1562232
    See related
    EnsemblRapid:ENSRNOG00000065756 AllianceGenome:RGD:1562232
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562232
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in centrosome; microfibril; and nucleoplasm. Predicted to be part of U2-type precatalytic spliceosome. Orthologous to human MFAP1 (microfibril associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 86.8), Muscle (RPKM 79.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mfap1a in Genome Data Viewer
    Location:
    3q35
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128893880..128910460, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108440163..108456744, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113428855..113445435, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene serine incorporator 4 Neighboring gene small EDRK-rich factor 2 Neighboring gene Huntingtin interacting protein K Neighboring gene WD repeat domain 76 Neighboring gene FERM domain containing 5 Neighboring gene uncharacterized LOC120101916

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of an associated microfibril protein through recombinant DNA techniques. Horrigan SK, et al. J Biol Chem, 1992 May 15. PMID 1374398
    2. Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Bertram K, et al. Cell, 2017 Aug 10. PMID 28781166
    3. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    4. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microfibril ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microfibrillar-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191964.1 → NP_001178893.1  microfibrillar-associated protein 1

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D4ACM9
      Related
      ENSRNOP00000021562.7, ENSRNOT00000021562.8
      Conserved Domains (1) summary
      pfam06991
      Location:197 → 399
      MFAP1; Microfibril-associated/Pre-mRNA processing

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      128893880..128910460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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