Msh2 mutS homolog 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Msh2provided by RGD
Official Full Name: mutS homolog 2provided by RGD
Primary source: RGD:620786
See related: EnsemblRapid:ENSRNOG00000015796 AllianceGenome:RGD:620786
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including ATP hydrolysis activity; DNA binding activity; and protein homodimerization activity. Predicted to contribute to several functions, including DNA binding activity; MutLalpha complex binding activity; and adenyl ribonucleotide binding activity. Involved in several processes, including response to amino acid; response to xenobiotic stimulus; and spermatogenesis. Predicted to be located in nucleoplasm. Predicted to be part of MutSalpha complex and MutSbeta complex. Predicted to be active in nucleus. Biomarker of colitis and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer (multiple); mismatch repair cancer syndrome; and transitional cell carcinoma. Orthologous to human MSH2 (mutS homolog 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 220.9), Adrenal (RPKM 108.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (12567368..12626534, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (6813793..6872960, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (11215951..11274916, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Potential Influence of Age and Diabetes Mellitus Type 1 on MSH2 (MutS homolog 2) Expression in a Rat Kidney Tissue.
Title: Potential Influence of Age and Diabetes Mellitus Type 1 on MSH2 (MutS homolog 2) Expression in a Rat Kidney Tissue.
overexpression of Msh2 did not protect the mitochondria damage. Termination of hyperglycemia failed to reverse decrease in MMR enzymes and increase in D-loop sequence variants.
Title: Retinal mitochondrial DNA mismatch repair in the development of diabetic retinopathy, and its continued progression after termination of hyperglycemia.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:549135 (e-PCR)
- UniSTS:157610

WI-18791 (e-PCR)
- UniSTS:28587

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP binding	IEA Inferred from Electronic Annotation more info
contributes_to ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
contributes_to ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables MutLalpha complex binding	IEA Inferred from Electronic Annotation more info
contributes_to MutLalpha complex binding	ISO Inferred from Sequence Orthology more info
enables centromeric DNA binding	IEA Inferred from Electronic Annotation more info
enables centromeric DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
contributes_to dinucleotide insertion or deletion binding	ISO Inferred from Sequence Orthology more info
enables dinucleotide repeat insertion binding	IEA Inferred from Electronic Annotation more info
contributes_to dinucleotide repeat insertion binding	ISO Inferred from Sequence Orthology more info
contributes_to double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables four-way junction DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to four-way junction DNA binding	ISO Inferred from Sequence Orthology more info
enables guanine/thymine mispair binding	IEA Inferred from Electronic Annotation more info
contributes_to guanine/thymine mispair binding	ISO Inferred from Sequence Orthology more info
enables guanine/thymine mispair binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
contributes_to magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables mismatched DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mismatched DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to mismatched DNA binding	ISO Inferred from Sequence Orthology more info
enables mismatched DNA binding	ISO Inferred from Sequence Orthology more info
enables oxidized purine DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to oxidized purine DNA binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables single guanine insertion binding	IEA Inferred from Electronic Annotation more info
contributes_to single guanine insertion binding	ISO Inferred from Sequence Orthology more info
enables single thymine insertion binding	IEA Inferred from Electronic Annotation more info
contributes_to single thymine insertion binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to single-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within B cell mediated immunity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in determination of adult lifespan	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in germ cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within germ cell development	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in isotype switching	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within isotype switching	ISO Inferred from Sequence Orthology more info
involved_in maintenance of DNA repeat elements	IEA Inferred from Electronic Annotation more info
involved_in maintenance of DNA repeat elements	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in mismatch repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mismatch repair	ISO Inferred from Sequence Orthology more info
involved_in mismatch repair	ISO Inferred from Sequence Orthology more info
involved_in mitotic intra-S DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic intra-S DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA recombination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA recombination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in oxidative phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of helicase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of isotype switching to IgA isotypes	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of isotype switching to IgA isotypes	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of isotype switching to IgG isotypes	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of isotype switching to IgG isotypes	ISO Inferred from Sequence Orthology more info
involved_in postreplication repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within postreplication repair	ISO Inferred from Sequence Orthology more info
involved_in postreplication repair	ISO Inferred from Sequence Orthology more info
involved_in postreplication repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to chromatin	IEA Inferred from Electronic Annotation more info
involved_in protein localization to chromatin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in response to UV-B	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in response to X-ray	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to X-ray	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in somatic hypermutation of immunoglobulin genes	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic recombination of immunoglobulin gene segments	ISO Inferred from Sequence Orthology more info
involved_in somatic recombination of immunoglobulin genes involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somatic recombination of immunoglobulin genes involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of MutSalpha complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MutSalpha complex	IEA Inferred from Electronic Annotation more info
part_of MutSalpha complex	ISO Inferred from Sequence Orthology more info
part_of MutSalpha complex	ISS Inferred from Sequence or Structural Similarity more info
part_of MutSbeta complex	IEA Inferred from Electronic Annotation more info
part_of MutSbeta complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA mismatch repair protein Msh2

Names: mismatch repair protein; mutS protein homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031058.2 → NP_112320.2 DNA mismatch repair protein Msh2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

P54275

UniProtKB/TrEMBL

B1WBQ7, F7FQ51

Related

ENSRNOP00000021538.3, ENSRNOT00000021538.9

Conserved Domains (1) summary

COG0249
Location:26 → 853

MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

12567368..12626534 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112994.2 → XP_038968922.1 DNA mismatch repair protein Msh2 isoform X1

UniProtKB/Swiss-Prot

P54275

Conserved Domains (1) summary

COG0249
Location:26 → 825

MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]