U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Uroc1 urocanase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 243537, updated on 27-Nov-2024

    Summary

    Official Symbol
    Uroc1provided by MGI
    Official Full Name
    urocanase domain containing 1provided by MGI
    Primary source
    MGI:MGI:2385332
    See related
    Ensembl:ENSMUSG00000034456 AllianceGenome:MGI:2385332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable urocanate hydratase activity. Predicted to be involved in L-histidine catabolic process. Predicted to be located in cytosol. Is expressed in alimentary system; liver; and liver lobe. Human ortholog(s) of this gene implicated in urocanase deficiency. Orthologous to human UROC1 (urocanate hydratase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 160.1), liver E18 (RPKM 41.1) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Uroc1 in Genome Data Viewer
    Location:
    6 D1; 6 40.15 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (90310221..90341533)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (90333239..90364551)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC048671 Neighboring gene carbohydrate sulfotransferase 13 Neighboring gene STARR-positive B cell enhancer ABC_E10392 Neighboring gene STARR-seq mESC enhancer starr_16614 Neighboring gene ZXD family zinc finger C Neighboring gene STARR-seq mESC enhancer starr_16615 Neighboring gene cilia and flagella associated protein 100 Neighboring gene predicted gene, 53295

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC37818

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables urocanate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables urocanate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables urocanate hydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in L-histidine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-histidine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-histidine catabolic process to glutamate and formamide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-histidine catabolic process to glutamate and formate IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    urocanate hydratase
    Names
    imidazolonepropionate hydrolase
    NP_001334258.1
    NP_659189.2
    XP_006506155.1
    XP_006506156.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347329.1NP_001334258.1  urocanate hydratase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC163346, AK149464
      Consensus CDS
      CCDS85094.1
      UniProtKB/TrEMBL
      Q3UEL5
      Related
      ENSMUSP00000127114.2, ENSMUST00000164761.6
    2. NM_144940.2NP_659189.2  urocanate hydratase isoform 2

      See identical proteins and their annotated locations for NP_659189.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AC163346, AK149464
      Consensus CDS
      CCDS39561.1
      UniProtKB/Swiss-Prot
      E9QNN2, Q8VC12
      Related
      ENSMUSP00000040424.10, ENSMUST00000046128.12
      Conserved Domains (1) summary
      PRK05414
      Location:74662
      PRK05414; urocanate hydratase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      90310221..90341533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506093.4XP_006506156.1  urocanate hydratase isoform X2

      Conserved Domains (1) summary
      cl19311
      Location:74448
      Urocanase; Urocanase Rossmann-like domain
    2. XM_006506092.2XP_006506155.1  urocanate hydratase isoform X1

      Conserved Domains (1) summary
      cl19311
      Location:1555
      Urocanase; Urocanase Rossmann-like domain