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    Egfl8 EGF-like domain 8 [ Mus musculus (house mouse) ]

    Gene ID: 81701, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Egfl8provided by MGI
    Official Full Name
    EGF-like domain 8provided by MGI
    Primary source
    MGI:MGI:1932094
    See related
    Ensembl:ENSMUSG00000015467 AllianceGenome:MGI:1932094
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ng3
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in vasculogenesis. Predicted to be active in cell surface and extracellular region. Is expressed in several structures, including diaphragm; genitourinary system; gut; hemolymphoid system gland; and trigeminal nerve. Orthologous to human EGFL8 (EGF like domain multiple 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in duodenum adult (RPKM 162.7), small intestine adult (RPKM 77.7) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Egfl8 in Genome Data Viewer
    Location:
    17 B1; 17 18.19 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34832174..34835536, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34613349..34616562, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene advanced glycosylation end product-specific receptor Neighboring gene STARR-positive B cell enhancer ABC_E45 Neighboring gene ring finger protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E11640 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene RIKEN cDNA 2610029K11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34767227-34767451 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34768061-34768244 Neighboring gene proline-rich transmembrane protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Descriptive and functional characterization of epidermal growth factor‑like domain 8 in mouse cortical thymic epithelial cells by integrated analysis of gene expression signatures and networks. Lim YS, et al. Int J Mol Med, 2021 Mar. PMID 33448309, Free PMC Article
    2. Molecular characterization and expression analysis of mouse epidermal growth factor-like domain 8. Song IJ, et al. Int J Mol Med, 2015 Aug. PMID 26096343
    3. Epidermal growth factor-like domain 8 inhibits the survival and proliferation of mouse thymocytes. Subhan F, et al. Int J Mol Med, 2013 Oct. PMID 23877103
    4. Regulatory role of mouse epidermal growth factor-like protein 8 in thymic epithelial cells. Choi HJ, et al. Biochem Biophys Res Commun, 2012 Aug 24. PMID 22828506
    5. Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells. Fitch MJ, et al. Dev Dyn, 2004 Jun. PMID 15162510, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Descriptive and functional characterization of epidermal growth factorlike domain 8 in mouse cortical thymic epithelial cells by integrated analysis of gene expression signatures and networks.
      Title: Descriptive and functional characterization of epidermal growth factor‑like domain 8 in mouse cortical thymic epithelial cells by integrated analysis of gene expression signatures and networks.
    2. Mouse EGFL8 encodes a protein of 293 amino acids with two EGFL domains, an Emilin-like domain and a Ca(2+)-binding EGFL domain, which has a molecular mass of 32 kDa.
      Title: Molecular characterization and expression analysis of mouse epidermal growth factor-like domain 8.
    3. EGFL8 inhibited thymocyte proliferation and induced thymocyte apoptosis.
      Title: Epidermal growth factor-like domain 8 inhibits the survival and proliferation of mouse thymocytes.
    4. these data show that EGFL8 exerts inhibitory effects on thymic epithelial cells and thymocytes, suggesting that EGFL8 acts as a negative regulatory molecule in the development of T cells in the mouse thymus.
      Title: Regulatory role of mouse epidermal growth factor-like protein 8 in thymic epithelial cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in in utero embryonic development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in vasculogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    epidermal growth factor-like protein 8
    Names
    EGF-like protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403845.1 → NP_001390774.1  epidermal growth factor-like protein 8 precursor

      Status: VALIDATED

      Source sequence(s)
      CT009767
      UniProtKB/Swiss-Prot
      O35447, Q3UFB4, Q6GUQ1
      UniProtKB/TrEMBL
      B9EJ41

    2. NM_152922.4 → NP_690886.3  epidermal growth factor-like protein 8 precursor

      See identical proteins and their annotated locations for NP_690886.3

      Status: VALIDATED

      Source sequence(s)
      CT009767
      Consensus CDS
      CCDS28651.1
      UniProtKB/Swiss-Prot
      O35447, Q3UFB4, Q6GUQ1
      UniProtKB/TrEMBL
      B7ZP51, B9EJ41
      Related
      ENSMUSP00000015611.8, ENSMUST00000015611.14
      Conserved Domains (2) summary
      smart00179
      Location:144 → 183
      EGF_CA; Calcium-binding EGF-like domain
      pfam07546
      Location:37 → 101
      EMI; EMI domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34832174..34835536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525180.5 → XP_006525243.1  epidermal growth factor-like protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006525243.1

      UniProtKB/TrEMBL
      E9QAK9
      Related
      ENSMUSP00000128433.3, ENSMUST00000168353.4
      Conserved Domains (2) summary
      smart00179
      Location:144 → 183
      EGF_CA; Calcium-binding EGF-like domain
      pfam07546
      Location:37 → 101
      EMI; EMI domain

    2. XM_036160852.1 → XP_036016745.1  epidermal growth factor-like protein 8 isoform X1

      UniProtKB/Swiss-Prot
      O35447, Q3UFB4, Q6GUQ1
      UniProtKB/TrEMBL
      B7ZP51, B9EJ41
      Conserved Domains (2) summary
      smart00179
      Location:144 → 183
      EGF_CA; Calcium-binding EGF-like domain
      pfam07546
      Location:37 → 101
      EMI; EMI domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GUQ1.2 GenPept UniProtKB/Swiss-Prot:Q6GUQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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