U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Klk8 kallikrein related-peptidase 8 [ Mus musculus (house mouse) ]

    Gene ID: 259277, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Klk8provided by MGI
    Official Full Name
    kallikrein related-peptidase 8provided by MGI
    Primary source
    MGI:MGI:1343327
    See related
    Ensembl:ENSMUSG00000064023 AllianceGenome:MGI:1343327
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NP; BSP1; Nrpn; Prss19
    Summary
    This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein exhibit impaired long-term potentiation and increased anxiety, as well as a hyperkeratosis phenotype. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]
    Expression
    Broad expression in stomach adult (RPKM 16.0), thymus adult (RPKM 5.0) and 17 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Klk8 in Genome Data Viewer
    Location:
    7 B3; 7 28.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43447001..43453250)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43797532..43803826)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene kallikrein related-peptidase 10 Neighboring gene kallikrein related-peptidase 9 Neighboring gene kallikrein related-peptidase 7 (chymotryptic, stratum corneum) Neighboring gene kallikrein related-peptidase 6

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Involvement of neuropsin in the pathogenesis of experimental autoimmune encephalomyelitis. Terayama R, et al. Glia, 2005 Nov 1. PMID 15920728
    2. Neuropsin (KLK8)-dependent and -independent synaptic tagging in the Schaffer-collateral pathway of mouse hippocampus. Ishikawa Y, et al. J Neurosci, 2008 Jan 23. PMID 18216192, Free PMC Article
    3. Increased anxiety-like behavior in neuropsin (kallikrein-related peptidase 8) gene-deficient mice. Horii Y, et al. Behav Neurosci, 2008 Jun. PMID 18513120
    4. Assignment of the neuropsin gene (Prss19) to mouse chromosome band 7B4 by in situ hybridization. Yoshida S, et al. Cytogenet Cell Genet, 2000. PMID 10773678
    5. Klk8, a multifunctional protease in the brain and skin: analysis of knockout mice. Yoshida S. Biol Chem, 2010 Apr. PMID 20180635

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1.
      Title: Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1.
    2. Genetic knockdown of Klk8 has sex-specific multi-targeted therapeutic effects on Alzheimer's pathology in mice.
      Title: Genetic knockdown of Klk8 has sex-specific multi-targeted therapeutic effects on Alzheimer's pathology in mice.
    3. A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.
      Title: A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.
    4. Klk8 knockout mice (NRG1-deactivated mice) exhibited normal social approach but impaired social discrimination
      Title: Impaired social discrimination behavior despite normal social approach by kallikrein-related peptidase 8 knockout mouse.
    5. KLK8 deficiency in mouse hippocampus reduced L1CAM cleavage and MAP2c levels and caused profound loss of dendrites. Disruption of dendrite growth impaired novel object recognition memory in KLK8 compromised mice possibly via inhibition of PKA/CREB signaling.
      Title: A serine protease KLK8 emerges as a regulator of regulators in memory: Microtubule protein dependent neuronal morphology and PKA-CREB signaling.
    6. Letter: NGF-p75 and neuropsin/KLK8 pathways may cooperate in regulation of epidermal homeostasis in inflamed skin.
      Title: NGF-p75 and neuropsin/KLK8 pathways stimulate each other to cause hyperkeratosis and acanthosis in inflamed skin.
    7. Klk8 is involved in the proliferation and migration of keratinocytes through Klk6 in the early stages of wound healing, and possibly in keratinocyte differentiation associated with the upregulation of PAR2 in the late stages of wound healing.
      Title: Kallikrein-related peptidase 8-dependent skin wound healing is associated with upregulation of kallikrein-related peptidase 6 and PAR2.
    8. KLK8 is involved in synaptic tagging during LTP at basal and apical dendritic inputs.
      Title: Diversity of neuropsin (KLK8)-dependent synaptic associativity in the hippocampal pyramidal neuron.
    9. the serine protease neuropsin is critical for stress-related plasticity in the amygdala by regulating the dynamics of the EphB2-NMDA-receptor interaction, the expression of Fkbp5 and anxiety-like behaviour
      Title: Neuropsin cleaves EphB2 in the amygdala to control anxiety.
    10. Klk8 might thus be involved in tissue development and rearrangement.
      Title: Klk8, a multifunctional protease in the brain and skin: analysis of knockout mice.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to wounding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of serine protease inhibitor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of serine protease inhibitor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    kallikrein-8
    Names
    Brain Serine protease 1
    protease, serine, 19 (neuropsin)
    NP_001311327.1
    NP_032966.1
    XP_030098463.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324398.1 → NP_001311327.1  kallikrein-8 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AB074296, AC151989, EH106421
      Consensus CDS
      CCDS21182.1
      UniProtKB/Swiss-Prot
      Q61955, Q8K5D7
      UniProtKB/TrEMBL
      A0A0B6VRH9, A0A0U1RNI7
      Related
      ENSMUSP00000145580.2, ENSMUST00000205537.2
      Conserved Domains (1) summary
      smart00020
      Location:32 → 252
      Tryp_SPc; Trypsin-like serine protease

    2. NM_008940.3 → NP_032966.1  kallikrein-8 preproprotein

      See identical proteins and their annotated locations for NP_032966.1

      Status: REVIEWED

      Source sequence(s)
      AB074296, AC151989, EH106421
      Consensus CDS
      CCDS21182.1
      UniProtKB/Swiss-Prot
      Q61955, Q8K5D7
      UniProtKB/TrEMBL
      A0A0B6VRH9, A0A0U1RNI7
      Related
      ENSMUSP00000082588.3, ENSMUST00000085461.4
      Conserved Domains (1) summary
      smart00020
      Location:32 → 252
      Tryp_SPc; Trypsin-like serine protease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      43447001..43453250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242603.2 → XP_030098463.1  kallikrein-8 isoform X1

      Conserved Domains (1) summary
      smart00020
      Location:1 → 131
      Tryp_SPc; Trypsin-like serine protease
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61955.1 GenPept UniProtKB/Swiss-Prot:Q61955

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous