Tfec transcription factor EC [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tfecprovided by MGI
Official Full Name: transcription factor ECprovided by MGI
Primary source: MGI:MGI:1333760
See related: Ensembl:ENSMUSG00000029553 AllianceGenome:MGI:1333760
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tcfec; bHLHe34
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to heat. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; gut; male reproductive gland or organ; trunk somite; and urinary system. Orthologous to human TFEC (transcription factor EC). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in placenta adult (RPKM 1.9), liver E18 (RPKM 1.4) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A2; 6 7.61 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (16830926..16898463, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (16830927..16898464, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tfec transcribes IL-4 receptor alpha expression to promote M2 programming in macrophages
Title: Role of C/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL-4/signal transducer and activator of transcription 6/transcription factor EC/IL-4 receptor α positive feedback loop in M2 macrophages.
Data indicate that FOS, SPI1, KLF10, TFEC, and PRDM16 show robust transcriptional cross-regulation and are often associated with osteoclastogenesis.
Title: Identification of non-cell-autonomous networks from engineered feeder cells that enhance murine hematopoietic stem cell activity.
Transcription factor EC, along with several other transcription factors, is a Stat6-dependent target of IL-4.
Title: Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB107417 (e-PCR)
- UniSTS:185655

Tcfec (e-PCR), detects polymorphism
- UniSTS:466085

RH94544 (e-PCR)
- UniSTS:119792

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription factor EC

Names: TFE-C; mTFEC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031198.3 → NP_112475.1 transcription factor EC

Status: VALIDATED

Source sequence(s)

AC102663, AK137141

Consensus CDS

CCDS19920.1

UniProtKB/Swiss-Prot

Q3TWR7, Q9WTW4

Related

ENSMUSP00000031533.8, ENSMUST00000031533.11

Conserved Domains (3) summary

cd00083
Location:108 → 168

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam11851
Location:196 → 300

DUF3371; Domain of unknown function (DUF3371)

cl21462
Location:164 → 195

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

16830926..16898463 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241053.3 → XP_011239355.1 transcription factor EC isoform X2

Conserved Domains (2) summary

pfam11851
Location:213 → 317

DUF3371; Domain of unknown function (DUF3371)

cl00081
Location:148 → 219

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_006505035.5 → XP_006505098.1 transcription factor EC isoform X1

Conserved Domains (2) summary

pfam11851
Location:232 → 336

DUF3371; Domain of unknown function (DUF3371)

cd18926
Location:135 → 238

bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
XM_017321504.2 → XP_017176993.1 transcription factor EC isoform X4

Conserved Domains (2) summary

pfam11851
Location:97 → 201

DUF3371; Domain of unknown function (DUF3371)

cl00081
Location:32 → 103

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_006505036.4 → XP_006505099.1 transcription factor EC isoform X3

Conserved Domains (2) summary

pfam11851
Location:158 → 262

DUF3371; Domain of unknown function (DUF3371)

cd18926
Location:61 → 164

bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
XM_006505037.4 → XP_006505100.1 transcription factor EC isoform X4

Conserved Domains (2) summary

pfam11851
Location:97 → 201

DUF3371; Domain of unknown function (DUF3371)

cl00081
Location:32 → 103

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily