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    Vsig1 V-set and immunoglobulin domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 78789, updated on 13-Jan-2025

    Summary

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    Official Symbol
    Vsig1provided by MGI
    Official Full Name
    V-set and immunoglobulin domain containing 1provided by MGI
    Primary source
    MGI:MGI:1926039
    See related
    Ensembl:ENSMUSG00000031430 AllianceGenome:MGI:1926039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700062D20Rik; 4930405J24Rik
    Summary
    Acts upstream of or within epithelial cell morphogenesis and maintenance of gastrointestinal epithelium. Located in basolateral plasma membrane. Is expressed in ovary; stomach; stomach glandular epithelium; stomach glandular region epithelium; and testis. Orthologous to human VSIG1 (V-set and immunoglobulin domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in stomach adult (RPKM 25.5), testis adult (RPKM 16.6) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Vsig1 in Genome Data Viewer
    Location:
    X F1; X 61.62 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (139808357..139840221)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (140907608..140939472)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene testis expressed 13B Neighboring gene ribosomal protein S7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48010 Neighboring gene STARR-positive B cell enhancer ABC_E3263 Neighboring gene STARR-seq mESC enhancer starr_48011 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 Neighboring gene autophagy related 4A, cysteine peptidase Neighboring gene STARR-positive B cell enhancer mm9_chrX:137591358-137591658 Neighboring gene collagen, type IV, alpha 6 Neighboring gene predicted gene, 39539

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional Pro-metastatic Heterogeneity Revealed by Spiked-scRNAseq Is Shaped by Cancer Cell Interactions and Restricted by VSIG1. Bernal C, et al. Cell Rep, 2020 Nov 10. PMID 33176137
    2. V-Set and Immunoglobulin Domain-Containing 1 (VSIG1), Predominantly Expressed in Testicular Germ Cells, Is Dispensable for Spermatogenesis and Male Fertility in Mice. Jung Y, et al. Animals (Basel), 2021 Apr 7. PMID 33916888, Free PMC Article
    3. Impairments to the GH-IGF-I axis in hSOD1G93A mice give insight into possible mechanisms of GH dysregulation in patients with amyotrophic lateral sclerosis. Steyn FJ, et al. Endocrinology, 2012 Aug. PMID 22621959
    4. Extracellular domain of V-set and immunoglobulin domain containing 1 (VSIG1) interacts with sertoli cell membrane protein, while its PDZ-binding motif forms a complex with ZO-1. Kim E, et al. Mol Cells, 2010 Nov. PMID 20957455
    5. Adhesion protein VSIG1 is required for the proper differentiation of glandular gastric epithelia. Oidovsambuu O, et al. PLoS One, 2011. PMID 21991385, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional Pro-metastatic Heterogeneity Revealed by Spiked-scRNAseq Is Shaped by Cancer Cell Interactions and Restricted by VSIG1.
      Title: Functional Pro-metastatic Heterogeneity Revealed by Spiked-scRNAseq Is Shaped by Cancer Cell Interactions and Restricted by VSIG1.
    2. VSIG1 is required for the establishment of glandular versus squamous epithelia in the stomach.
      Title: Adhesion protein VSIG1 is required for the proper differentiation of glandular gastric epithelia.
    3. mouse VSIG1 interacts with Sertoli cells by heterophilic adhesion via its first Ig-like domain
      Title: Extracellular domain of V-set and immunoglobulin domain containing 1 (VSIG1) interacts with sertoli cell membrane protein, while its PDZ-binding motif forms a complex with ZO-1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within epithelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of gastrointestinal epithelium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within maintenance of gastrointestinal epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    V-set and immunoglobulin domain-containing protein 1
    Names
    cell surface A33 antigen
    glycoprotein A34

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359143.1 → NP_001346072.1  V-set and immunoglobulin domain-containing protein 1 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AK132956, BC145050
      UniProtKB/Swiss-Prot
      Q9D2J4, Q9D9J0, Q9DA22
      UniProtKB/TrEMBL
      B7ZN70
      Conserved Domains (2) summary
      pfam13927
      Location:180 → 253
      Ig_3; Immunoglobulin domain
      cl11960
      Location:24 → 165
      Ig; Immunoglobulin domain

    2. NM_026103.1 → NP_080379.1  V-set and immunoglobulin domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 5' UTR and lacks part of the 5' coding region with the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK006862, AK132956
      UniProtKB/Swiss-Prot
      Q9D2J4
      Conserved Domains (3) summary
      smart00409
      Location:47 → 122
      IG; Immunoglobulin
      cl11960
      Location:1 → 22
      Ig; Immunoglobulin domain
      cl29137
      Location:207 → 252
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)

    3. NM_030181.3 → NP_084457.2  V-set and immunoglobulin domain-containing protein 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. It encodes the longer protein (isoform 1).
      Source sequence(s)
      AK132956
      Consensus CDS
      CCDS30443.1
      UniProtKB/Swiss-Prot
      Q9D2J4, Q9D9J0, Q9DA22
      UniProtKB/TrEMBL
      A0A0B4J1E9
      Related
      ENSMUSP00000033806.5, ENSMUST00000033806.5
      Conserved Domains (3) summary
      cd00096
      Location:159 → 226
      Ig; Immunoglobulin domain
      smart00410
      Location:154 → 229
      IG_like; Immunoglobulin like
      cl11960
      Location:25 → 129
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      139808357..139840221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528631.5 → XP_006528694.1  V-set and immunoglobulin domain-containing protein 1 isoform X1

      Related
      ENSMUST00000127629.2
      Conserved Domains (3) summary
      smart00409
      Location:47 → 122
      IG; Immunoglobulin
      cl11960
      Location:1 → 22
      Ig; Immunoglobulin domain
      cl29137
      Location:207 → 252
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2J4.1 GenPept UniProtKB/Swiss-Prot:Q9D2J4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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