Med13l mediator complex subunit 13-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Med13lprovided by MGI
Official Full Name: mediator complex subunit 13-likeprovided by MGI
Primary source: MGI:MGI:2670178
See related: Ensembl:ENSMUSG00000018076 AllianceGenome:MGI:2670178
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Thrap2; Trap240L; mKIAA1025; 2210413I17Rik; 6330591G05Rik; 9030618F05Rik
Summary: Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within transcription by RNA polymerase II. Part of mediator complex. Is expressed in 1-cell stage embryo; 2-cell stage embryo; cortical plate; and primary oocyte. Human ortholog(s) of this gene implicated in dextro-looped transposition of the great arteries. Orthologous to human MED13L (mediator complex subunit 13L). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 10.1), spleen adult (RPKM 6.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 59.1 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (118698363..118903503)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (118560330..118765438)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MED13L and its disease-associated variants influence the dendritic development of cerebral cortical neurons in the mammalian brain.
Title: MED13L and its disease-associated variants influence the dendritic development of cerebral cortical neurons in the mammalian brain.
Expression Analyses of Mediator Complex Subunit 13-Like: A Responsible Gene for Neurodevelopmental Disorders during Mouse Brain Development.
Title: Expression Analyses of Mediator Complex Subunit 13-Like: A Responsible Gene for Neurodevelopmental Disorders during Mouse Brain Development.
this study shows that Med13L polymorphisms between the B10.RIII and RIIIS/J mouse strains do not affect immune phenotype, collagen-induced arthritis development and autoantibody production in these mice
Title: Analysis of Polymorphisms in the Mediator Complex Subunit 13-like (Med13L) Gene in the Context of Immune Function and Development of Experimental Arthritis.
Transcripts were most abundant in heart.
Title: cDNA cloning and characterization of the human THRAP2 gene which maps to chromosome 12q24, and its mouse ortholog Thrap2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126676 (e-PCR)
- UniSTS:167425

NoName (e-PCR)
- UniSTS:235294

43.MMHAP25FLG4.seq (e-PCR)
- UniSTS:124493

D5Mit136 (e-PCR), detects polymorphism
- UniSTS:116313

BE225839 (e-PCR)
- UniSTS:207862

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transcription by RNA polymerase II	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: mediator of RNA polymerase II transcription subunit 13-like

Names: thyroid hormone receptor associated protein 2; thyroid hormone receptor-associated protein complex 240 kDa component-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347445.2 → NP_001334374.1 mediator of RNA polymerase II transcription subunit 13-like isoform 1

Status: VALIDATED

Source sequence(s)

AC117585, AC129552

Consensus CDS

CCDS84948.1

UniProtKB/Swiss-Prot

Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0

UniProtKB/TrEMBL

A0A0J9YUA8

Related

ENSMUSP00000144092.2, ENSMUST00000201010.2
NM_172424.5 → NP_766012.3 mediator of RNA polymerase II transcription subunit 13-like isoform 2

See identical proteins and their annotated locations for NP_766012.3

Status: VALIDATED

Source sequence(s)

AC117585, AC129552

Consensus CDS

CCDS57375.1

UniProtKB/Swiss-Prot

Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0

UniProtKB/TrEMBL

E9QLJ3

Related

ENSMUSP00000098379.5, ENSMUST00000100816.8

Conserved Domains (2) summary

pfam06333
Location:1675 → 2194

Med13_C; Mediator complex subunit 13 C-terminal

pfam11597
Location:16 → 380

Med13_N; Mediator complex subunit 13 N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

118698363..118903503

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254882.2 → XP_030110742.1 mediator of RNA polymerase II transcription subunit 13-like isoform X2

UniProtKB/Swiss-Prot

Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0

Conserved Domains (3) summary

pfam06333
Location:1792 → 2195

Med13_C; Mediator complex subunit 13 C-terminal

pfam11597
Location:11 → 287

Med13_N; Mediator complex subunit 13 N-terminal

pfam18296
Location:1414 → 1756

MID_MedPIWI; MID domain of medPIWI
XM_011248248.4 → XP_011246550.1 mediator of RNA polymerase II transcription subunit 13-like isoform X1

UniProtKB/Swiss-Prot

Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0

Conserved Domains (3) summary

pfam06333
Location:1792 → 2204

Med13_C; Mediator complex subunit 13 C-terminal

pfam11597
Location:11 → 287

Med13_N; Mediator complex subunit 13 N-terminal

pfam18296
Location:1414 → 1756

MID_MedPIWI; MID domain of medPIWI
XM_036165591.1 → XP_036021484.1 mediator of RNA polymerase II transcription subunit 13-like isoform X3

UniProtKB/Swiss-Prot

Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0

Conserved Domains (2) summary

pfam06333
Location:1659 → 2071

Med13_C; Mediator complex subunit 13 C-terminal

pfam18296
Location:1281 → 1623

MID_MedPIWI; MID domain of medPIWI
XM_030254883.1 → XP_030110743.1 mediator of RNA polymerase II transcription subunit 13-like isoform X3

UniProtKB/Swiss-Prot

Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0

Conserved Domains (2) summary

pfam06333
Location:1659 → 2071

Med13_C; Mediator complex subunit 13 C-terminal

pfam18296
Location:1281 → 1623

MID_MedPIWI; MID domain of medPIWI