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    Erap1 endoplasmic reticulum aminopeptidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 80898, updated on 4-Jan-2025

    Summary

    Official Symbol
    Erap1provided by MGI
    Official Full Name
    endoplasmic reticulum aminopeptidase 1provided by MGI
    Primary source
    MGI:MGI:1933403
    See related
    Ensembl:ENSMUSG00000021583 AllianceGenome:MGI:1933403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A-LAP; Arts1; ERAAP; PILSA; ARTS-1; PILSAP
    Summary
    Enables aminopeptidase activity. Acts upstream of or within positive regulation of angiogenesis and proteolysis. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Human ortholog(s) of this gene implicated in cervix carcinoma. Orthologous to human ERAP1 (endoplasmic reticulum aminopeptidase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in bladder adult (RPKM 8.6), large intestine adult (RPKM 8.2) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Erap1 in Genome Data Viewer
    Location:
    13 C1; 13 40.48 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74787692..74841321)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (74639573..74693205)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57808 Neighboring gene STARR-seq mESC enhancer starr_35022 Neighboring gene predicted gene, 57809 Neighboring gene STARR-seq mESC enhancer starr_35023 Neighboring gene predicted gene, 46430 Neighboring gene STARR-positive B cell enhancer ABC_E10801 Neighboring gene calpastatin Neighboring gene STARR-positive B cell enhancer ABC_E5406 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35025 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like 2, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity PubMed 
    enables aminopeptidase activity  
    enables aminopeptidase activity  
    enables endopeptidase activity  
    enables interleukin-6 receptor binding  
    enables interleukin-6 receptor binding  
    enables metalloaminopeptidase activity  
    enables metalloexopeptidase activity  
    enables metalloexopeptidase activity  
    enables peptidase activity PubMed 
    enables peptide binding  
    enables tumor necrosis factor receptor binding  
    enables zinc ion binding  
    enables zinc ion binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in adaptive immune response  
    involved_in membrane protein ectodomain proteolysis  
    involved_in membrane protein ectodomain proteolysis  
    involved_in peptide catabolic process  
    acts_upstream_of_or_within positive regulation of angiogenesis PubMed 
    involved_in protein catabolic process  
    involved_in proteolysis  
    acts_upstream_of_or_within proteolysis PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in endoplasmic reticulum lumen  
    located_in endoplasmic reticulum membrane  
    located_in extracellular region  
    located_in extracellular region  
    is_active_in extracellular space  
    is_active_in membrane  

    General protein information

    Preferred Names
    endoplasmic reticulum aminopeptidase 1
    Names
    VEGF-induced aminopeptidase
    adipocyte-derived leucine aminopeptidase
    aminopeptidase PILS
    puromycin-insensitive leucyl-specific aminopeptidase
    type 1 tumor necrosis factor receptor shedding aminopeptidase regulator

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426580.1NP_001413509.1  endoplasmic reticulum aminopeptidase 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC138120
      UniProtKB/Swiss-Prot
      Q6GTP5, Q9EQH2, Q9ET63
    2. NM_001426581.1NP_001413510.1  endoplasmic reticulum aminopeptidase 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC138120
    3. NM_030711.6NP_109636.1  endoplasmic reticulum aminopeptidase 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_109636.1

      Status: VALIDATED

      Source sequence(s)
      AC138120
      Consensus CDS
      CCDS26647.1
      UniProtKB/Swiss-Prot
      Q6GTP5, Q9EQH2, Q9ET63
      Related
      ENSMUSP00000133166.2, ENSMUST00000169114.3
      Conserved Domains (2) summary
      cd09601
      Location:50515
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:586905
      ERAP1_C; ERAP1-like C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      74787692..74841321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247471.1XP_030103331.1  endoplasmic reticulum aminopeptidase 1 isoform X2

      Conserved Domains (2) summary
      cd09601
      Location:50515
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:586881
      ERAP1_C; ERAP1-like C-terminal domain
    2. XM_006517476.5XP_006517539.1  endoplasmic reticulum aminopeptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006517539.1

      UniProtKB/Swiss-Prot
      Q6GTP5, Q9EQH2, Q9ET63
      Conserved Domains (2) summary
      cd09601
      Location:50515
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:586905
      ERAP1_C; ERAP1-like C-terminal domain
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