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    Pabpc5 poly(A) binding protein, cytoplasmic 5 [ Mus musculus (house mouse) ]

    Gene ID: 93728, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pabpc5provided by MGI
    Official Full Name
    poly(A) binding protein, cytoplasmic 5provided by MGI
    Primary source
    MGI:MGI:2136401
    See related
    Ensembl:ENSMUSG00000034732 AllianceGenome:MGI:2136401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C820015E17
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human PABPC5 (poly(A) binding protein cytoplasmic 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Pabpc5 in Genome Data Viewer
    Location:
    X E1; X 49.58 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (118836893..118839862)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (119927196..119930165)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 C-like Neighboring gene STARR-seq mESC enhancer starr_47849 Neighboring gene predicted gene, 26182 Neighboring gene STARR-seq mESC enhancer starr_47850 Neighboring gene STARR-seq mESC enhancer starr_47851 Neighboring gene STARR-seq mESC enhancer starr_47852 Neighboring gene STARR-seq mESC enhancer starr_47853 Neighboring gene STARR-seq mESC enhancer starr_47854 Neighboring gene STARR-seq mESC enhancer starr_47855 Neighboring gene S-adenosylhomocysteine hydrolase pseudogene Neighboring gene SET translocation pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific subinterval in the Xq21.3/Yp11.2 homology block of the human sex chromosomes. Blanco P, et al. Genomics, 2001 May 15. PMID 11374897
    2. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130340, MGC130341

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    polyadenylate-binding protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053114.2 → NP_444344.1  polyadenylate-binding protein 5

      See identical proteins and their annotated locations for NP_444344.1

      Status: VALIDATED

      Source sequence(s)
      AK050551
      Consensus CDS
      CCDS30369.1
      UniProtKB/TrEMBL
      Q8C7D3
      Related
      ENSMUSP00000047756.3, ENSMUST00000040961.3
      Conserved Domains (5) summary
      cd12378
      Location:21 → 97
      RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
      cd12379
      Location:103 → 178
      RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
      cd12380
      Location:197 → 276
      RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
      TIGR01661
      Location:28 → 270
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:300 → 376
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      118836893..118839862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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