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    Lnx2 ligand of numb-protein X 2 [ Mus musculus (house mouse) ]

    Gene ID: 140887, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lnx2provided by MGI
    Official Full Name
    ligand of numb-protein X 2provided by MGI
    Primary source
    MGI:MGI:2155959
    See related
    Ensembl:ENSMUSG00000016520 AllianceGenome:MGI:2155959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9630046H24
    Summary
    Enables PDZ domain binding activity and identical protein binding activity. Acts upstream of or within neural precursor cell proliferation and neuron differentiation. Located in plasma membrane. Is expressed in several structures, including brain; early embryo; gonad; hemolymphoid system gland; and musculature. Orthologous to human LNX2 (ligand of numb-protein X 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 17.5), ovary adult (RPKM 17.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lnx2 in Genome Data Viewer
    Location:
    5 G3; 5 86.69 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (146953471..147013364, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147016655..147076572, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10366 Neighboring gene STARR-seq mESC enhancer starr_14863 Neighboring gene general transcription factor III A Neighboring gene STARR-seq mESC enhancer starr_14864 Neighboring gene mitochondrial translational initiation factor 3 Neighboring gene predicted gene, 46936 Neighboring gene STARR-positive B cell enhancer ABC_E6405 Neighboring gene STARR-positive B cell enhancer ABC_E6406 Neighboring gene STARR-seq mESC enhancer starr_14866 Neighboring gene STARR-positive B cell enhancer ABC_E2184 Neighboring gene STARR-positive B cell enhancer ABC_E8092 Neighboring gene polymerase (RNA) I polypeptide D Neighboring gene ribosomal protein S10, pseudogene 4 Neighboring gene STARR-seq mESC enhancer starr_14868 Neighboring gene predicted gene, 34994

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Impaired Blastocyst Formation in Lnx2-Knockdown Mouse Embryos. Lee SJ, et al. Int J Mol Sci, 2023 Jan 10. PMID 36674899, Free PMC Article
    2. Ubiquitin E3 Ligase LNX2 is Critical for Osteoclastogenesis In Vitro by Regulating M-CSF/RANKL Signaling and Notch2. Zhou J, et al. Calcif Tissue Int, 2015 May. PMID 25712254, Free PMC Article
    3. The cell surface protein coxsackie- and adenovirus receptor (CAR) directly associates with the Ligand-of-Numb Protein-X2 (LNX2). Mirza M, et al. Exp Cell Res, 2005 Sep 10. PMID 15979067
    4. Coxsackievirus and adenovirus receptor (CAR) is expressed in male germ cells and forms a complex with the differentiation factor JAM-C in mouse testis. Mirza M, et al. Exp Cell Res, 2006 Apr 1. PMID 16410001
    5. Caspr4 interaction with LNX2 modulates the proliferation and neuronal differentiation of mouse neural progenitor cells. Yin FT, et al. Stem Cells Dev, 2015 Mar 1. PMID 25279559, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Impaired Blastocyst Formation in Lnx2-Knockdown Mouse Embryos.
      Title: Impaired Blastocyst Formation in Lnx2-Knockdown Mouse Embryos.
    2. conclude that LNX2 regulates M-CSF/RANKL and the Notch signaling pathways during osteoclastogenesis
      Title: Ubiquitin E3 Ligase LNX2 is Critical for Osteoclastogenesis In Vitro by Regulating M-CSF/RANKL Signaling and Notch2.
    3. Caspr4 inhibits neuronal differentiation in a LNX-dependent manner.
      Title: Caspr4 interaction with LNX2 modulates the proliferation and neuronal differentiation of mouse neural progenitor cells.
    4. coxsackievirus and adenovirus receptor is a partner in a protein complex organized at specific subcellular sites by LNX2
      Title: The cell surface protein coxsackie- and adenovirus receptor (CAR) directly associates with the Ligand-of-Numb Protein-X2 (LNX2).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ligand of Numb protein X 2
    Names
    numb-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424753.1 → NP_001411682.1  ligand of Numb protein X 2

      Status: VALIDATED

      Source sequence(s)
      AL513345
      UniProtKB/Swiss-Prot
      A6PW04, Q8CBE1, Q91XL2
      UniProtKB/TrEMBL
      Q0VGP5, Q148W6

    2. NM_001424754.1 → NP_001411683.1  ligand of Numb protein X 2

      Status: VALIDATED

      Source sequence(s)
      AL513345
      UniProtKB/Swiss-Prot
      A6PW04, Q8CBE1, Q91XL2
      UniProtKB/TrEMBL
      Q0VGP5, Q148W6

    3. NM_080795.5 → NP_542985.4  ligand of Numb protein X 2

      See identical proteins and their annotated locations for NP_542985.4

      Status: VALIDATED

      Source sequence(s)
      AL513345
      Consensus CDS
      CCDS19875.1
      UniProtKB/Swiss-Prot
      A6PW04, Q8CBE1, Q91XL2
      UniProtKB/TrEMBL
      Q0VGP5, Q148W6
      Related
      ENSMUSP00000016664.8, ENSMUST00000016664.8
      Conserved Domains (3) summary
      smart00228
      Location:229 → 315
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:596 → 680
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd16780
      Location:46 → 90
      mRING-HC-C3HC3D_LNX2; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 2 (LNX2)

    RNA

    1. NR_188904.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL513345

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      146953471..147013364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504800.4 → XP_006504863.1  ligand of Numb protein X 2 isoform X1

      See identical proteins and their annotated locations for XP_006504863.1

      UniProtKB/Swiss-Prot
      A6PW04, Q8CBE1, Q91XL2
      UniProtKB/TrEMBL
      Q0VGP5, Q148W6
      Conserved Domains (3) summary
      smart00228
      Location:229 → 315
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:596 → 680
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd16780
      Location:46 → 90
      mRING-HC-C3HC3D_LNX2; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 2 (LNX2)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XL2.2 GenPept UniProtKB/Swiss-Prot:Q91XL2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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