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    exoY adenylate cyclase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879421, updated on 24-Aug-2024

    Summary

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    Gene symbol
    exoY
    Gene description
    adenylate cyclase
    Locus tag
    PA2191
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (2410344..2411480, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hydrogen cyanide synthase subunit HcnA Neighboring gene hydrogen cyanide synthase subunit HcnB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation. Beckert U, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24971548, Free PMC Article
    2. Adenylate cyclase activity of Pseudomonas aeruginosa ExoY can mediate bleb-niche formation in epithelial cells and contributes to virulence. Hritonenko V, et al. Microb Pathog, 2011 Nov. PMID 21843628, Free PMC Article
    3. The Role of Pseudomonas aeruginosa ExoY in an Acute Mouse Lung Infection Model. Kloth C, et al. Toxins (Basel), 2018 May 4. PMID 29734720, Free PMC Article
    4. Actin cytoskeleton disruption by ExoY and its effects on Pseudomonas aeruginosa invasion. Cowell BA, et al. FEMS Microbiol Lett, 2005 Sep 1. PMID 16039071
    5. Paradoxical cAMP-induced lung endothelial hyperpermeability revealed by Pseudomonas aeruginosa ExoY. Sayner SL, et al. Circ Res, 2004 Jul 23. PMID 15192021

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results suggest that the nucleotidyl cyclase activity of ExoY can contribute to P. aeruginosa acute pathogenicity.
      Title: The Role of Pseudomonas aeruginosa ExoY in an Acute Mouse Lung Infection Model.
    2. Here, we report that Pseudomonas aeruginosa ExoY inhibits proinflammatory cytokine production through suppressing the activation of TAK1 as well as downstream NF-kappaB and mitogen-activated protein (MAP) kinases.
      Title: Bacterial Nucleotidyl Cyclase Inhibits the Host Innate Immune Response by Suppressing TAK1 Activation.
    3. Thus, ExoY is a nucleotidyl cyclase with preference for cGMP and cUMP production
      Title: ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation.
    4. Adenylate cyclase activity of ExoY mediates bleb-niche formation in epithelial cells and contributes to virulence.
      Title: Adenylate cyclase activity of Pseudomonas aeruginosa ExoY can mediate bleb-niche formation in epithelial cells and contributes to virulence.
    5. actin disruption of epithelial cells at 2 h post-infection associated with both adenylate cyclase-active ExoY and its catalytic mutant form ExoYK81M, and which coincided with inhibition of bacterial invasion
      Title: Actin cytoskeleton disruption by ExoY and its effects on Pseudomonas aeruginosa invasion.
    6. ExoY synthesizes a cAMP pool that is distinct from the endogenous pool in its location and regulation by phosphodiesterases. ExoY-induced cAMP elevations are endothelial barrier disruptive, in contrast to endogenous cAMP which is barrier protective.
      Title: Paradoxical cAMP-induced lung endothelial hyperpermeability revealed by Pseudomonas aeruginosa ExoY.
    7. Role in systemic spread of Pseudomonas aeruginosa PAO1 in vivo
      Title: Role of the type III secreted exoenzymes S, T, and Y in systemic spread of Pseudomonas aeruginosa PAO1 in vivo.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    adenylate cyclase
    NP_250881.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      2410344..2411480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_250881.1 adenylate cyclase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_250881.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6B7EIT3
      Conserved Domains (1) summary
      pfam03497
      Location:37 → 202
      Anthrax_toxA; Anthrax toxin LF subunit
    Nucleotide Protein
    Heading Accession and Version

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