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    lecB fucose-binding lectin PA-IIL [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882528, updated on 24-Aug-2024

    Summary

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    Gene symbol
    lecB
    Gene description
    fucose-binding lectin PA-IIL
    Locus tag
    PA3361
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (3773029..3773376)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene secretion protein Neighboring gene transporter protein AmiS Neighboring gene aliphatic amidase regulator Neighboring gene aliphatic amidase expression-regulating protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LecB, a High Affinity Soluble Fucose-Binding Lectin from Pseudomonas aeruginosa. Gillon E, et al. Methods Mol Biol, 2020. PMID 32306354
    2. The Pseudomonas aeruginosa Lectin LecB Causes Integrin Internalization and Inhibits Epithelial Wound Healing. Thuenauer R, et al. mBio, 2020 Mar 10. PMID 32156827, Free PMC Article
    3. Glycosylation is required for outer membrane localization of the lectin LecB in Pseudomonas aeruginosa. Bartels KM, et al. J Bacteriol, 2011 Mar. PMID 21217000, Free PMC Article
    4. Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding. Gajdos L, et al. Nat Commun, 2022 Jan 11. PMID 35017516, Free PMC Article
    5. Pseudomonas aeruginosa lectin LecB is located in the outer membrane and is involved in biofilm formation. Tielker D, et al. Microbiology (Reading), 2005 May. PMID 15870442

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding.
      Title: Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding.
    2. LecB, a High Affinity Soluble Fucose-Binding Lectin from Pseudomonas aeruginosa.
      Title: LecB, a High Affinity Soluble Fucose-Binding Lectin from Pseudomonas aeruginosa.
    3. The Pseudomonas aeruginosa Lectin LecB Causes Integrin Internalization and Inhibits Epithelial Wound Healing.
      Title: The Pseudomonas aeruginosa Lectin LecB Causes Integrin Internalization and Inhibits Epithelial Wound Healing.
    4. Study demonstrates that Pseudomonas aeruginosa LecB binds to Psl, a key matrix exopolysaccharide (EPS), and this leads to increased retention of both cells and EPS in a growing biofilm. This interaction is predicted to occur between the LecB and the branched side chains present on Psl and coordinates Psl localization in the biofilm.
      Title: The Pseudomonas aeruginosa lectin LecB binds to the exopolysaccharide Psl and stabilizes the biofilm matrix.
    5. LecB binds to the outer membrane protein OprF
      Title: Specific association of lectin LecB with the surface of Pseudomonas aeruginosa: role of outer membrane protein OprF.
    6. It was reported that LecB is present in the periplasm of P. aeruginosa in two variants of different sizes and that glycosylation is required for the transport of LecB.
      Title: Glycosylation is required for outer membrane localization of the lectin LecB in Pseudomonas aeruginosa.
    7. The results demonstrate that there is a relationship between the LecA and LecB lectins and the pathogenicity of P. aeruginosa.
      Title: Role of LecA and LecB lectins in Pseudomonas aeruginosa-induced lung injury and effect of carbohydrate ligands.
    8. Altering specificity loop amino acids causes changes in the saccharide-binding preferences of lectins derived from PA-IIL, via creation or blocking possible binding interactions.
      Title: Engineering of PA-IIL lectin from Pseudomonas aeruginosa - Unravelling the role of the specificity loop for sugar preference.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within single-species biofilm formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fucose-binding lectin PA-IIL
    NP_252051.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      3773029..3773376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_252051.1 fucose-binding lectin PA-IIL [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_252051.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0N9LSG8
      Conserved Domains (1) summary
      pfam07472
      Location:7 → 114
      PA-IIL; Fucose-binding lectin II (PA-IIL)
    Nucleotide Protein
    Heading Accession and Version

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