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    algA bifunctional mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879142, updated on 24-Aug-2024

    Summary

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    Gene symbol
    algA
    Gene description
    bifunctional mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase
    Locus tag
    PA3551
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (3978031..3979476)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene alginate o-acetylase AlgJ Neighboring gene alginate o-acetyltransferase AlgF Neighboring gene UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase Neighboring gene undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase Neighboring gene bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase Neighboring gene 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of phosphomannose isomerase-guanosine diphospho-D-mannose pyrophosphorylase. A bifunctional enzyme in the alginate biosynthetic pathway of Pseudomonas aeruginosa. Shinabarger D, et al. J Biol Chem, 1991 Feb 5. PMID 1846611
    2. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    3. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
    4. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article
    5. A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance. Salunkhe P, et al. J Bacteriol, 2005 Jul. PMID 15995206, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables mannose-1-phosphate guanylyltransferase (GTP) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannose-6-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within alginic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase
    NP_252241.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      3978031..3979476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_252241.1 bifunctional mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_252241.1

      Status: PROVISIONAL

      Conserved Domains (1) summary
      TIGR01479
      Location:1 → 468
      GMP_PMI; mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07874.3

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