GRM5 glutamate metabotropic receptor 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GRM5provided by HGNC
Official Full Name: glutamate metabotropic receptor 5provided by HGNC
Primary source: HGNC:HGNC:4597
See related: Ensembl:ENSG00000168959 MIM:604102; AllianceGenome:HGNC:4597
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: mGlu5; GPRC1E; MGLUR5; PPP1R86
Summary: This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression: Restricted expression toward brain (RPKM 10.2) See more
Orthologs: mouse all
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Genomic context

Location:: 11q14.2-q14.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (88504642..89065982, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (88423789..88985122, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (88237810..88799150, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Metabotropic Glutamate Receptor 5 as a Potential Biomarker of the Intersection of Trauma and Cannabis Use.
Title: Metabotropic Glutamate Receptor 5 as a Potential Biomarker of the Intersection of Trauma and Cannabis Use.
Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder.
Title: Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder.
Stepwise activation of a metabotropic glutamate receptor.
Title: Stepwise activation of a metabotropic glutamate receptor.
Voltage tunes mGlu5 receptor function, impacting synaptic transmission.
Title: Voltage tunes mGlu(5) receptor function, impacting synaptic transmission.
Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer's disease: A [[18]F]PSS232 PET/MRI study.
Title: Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer's disease: A [(18)F]PSS232 PET/MRI study.
Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis.
Title: Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis.
Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.
Title: Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.
Inhibition of mGluR5 ameliorates lipid accumulation and inflammation in HepG2 cells.
Title: Inhibition of mGluR5 ameliorates lipid accumulation and inflammation in HepG2 cells.
From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems.
Title: From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems.
[Association of glutamate receptor metabotropic 5 polymorphisms with schizophrenia susceptibility in a Chinese Han population].
Title: [Association of glutamate receptor metabotropic 5 polymorphisms with schizophrenia susceptibility in a Chinese Han population].

Submit: New GeneRIF Correction See all GeneRIFs (97)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common genetic variation and the control of HIV-1 in humans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study in German patients with attention deficit/hyperactivity disorder. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of tanning phenotype in a population of European ancestry. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	The gene expression of GRM5 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH17467 (e-PCR)
- UniSTS:48642

SHGC-31451 (e-PCR)
- UniSTS:55323

D11S2309E (e-PCR)
- UniSTS:25628

D11S3366 (e-PCR)
- UniSTS:152608

G02188 (e-PCR)
- UniSTS:14372

D11S3643 (e-PCR)
- UniSTS:152880

D11S2470 (e-PCR)
- UniSTS:79673

G02206 (e-PCR)
- UniSTS:79676

G02157 (e-PCR)
- UniSTS:79677

G02180 (e-PCR)
- UniSTS:79679

D11S3024 (e-PCR)
- UniSTS:152127

G02154 (e-PCR)
- UniSTS:79681

G02211 (e-PCR)
- UniSTS:79682

SGC30871 (e-PCR)
- UniSTS:33861

SHGC-132429 (e-PCR)
- UniSTS:173898

SHGC-106865 (e-PCR)
- UniSTS:170063

G02201 (e-PCR)
- UniSTS:79953

G02351 (e-PCR)
- UniSTS:73822

G02171 (e-PCR)
- UniSTS:4463

WI-18462 (e-PCR)
- UniSTS:55409

RH40050 (e-PCR)
- UniSTS:87923

G02159 (e-PCR)
- UniSTS:2939

SHGC-144777 (e-PCR)
- UniSTS:172412

G02204 (e-PCR)
- UniSTS:56975

G02158 (e-PCR)
- UniSTS:43153

D11S2614 (e-PCR)
- UniSTS:43155

G02181 (e-PCR)
- UniSTS:43156

G02176 (e-PCR)
- UniSTS:43157

G02179 (e-PCR)
- UniSTS:43158

RH118911 (e-PCR)
- UniSTS:138903

G02190 (e-PCR)
- UniSTS:43159

G02198 (e-PCR)
- UniSTS:43162

G02187 (e-PCR)
- UniSTS:43163

G02199 (e-PCR)
- UniSTS:43164

G02191 (e-PCR)
- UniSTS:43165

RH120713 (e-PCR)
- UniSTS:132794

D11S3789 (e-PCR)
- UniSTS:153019

RH78484 (e-PCR)
- UniSTS:7376

D11S1367 (e-PCR), detects polymorphism
- UniSTS:50128

G02314 (e-PCR)
- UniSTS:79828

G43313 (e-PCR)
- UniSTS:94934

G64931 (e-PCR)
- UniSTS:167667

D11S1109 (e-PCR)
- UniSTS:77304

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables A2A adenosine receptor binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled glutamate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to amyloid-beta	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in cognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in desensitization of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in learning	IEA Inferred from Electronic Annotation more info
involved_in learning or memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium-mediated signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of long-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
located_in astrocyte projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: metabotropic glutamate receptor 5

Names: glutamate receptor, metabotropic 5; protein phosphatase 1, regulatory subunit 86

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052831.1 RefSeqGene

Range

4990..566330

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000842.5 → NP_000833.1 metabotropic glutamate receptor 5 isoform b precursor

See identical proteins and their annotated locations for NP_000833.1

Status: REVIEWED

Source sequence(s)

AP000626, AP001482, AP001828, AP003120, AP006215

Consensus CDS

CCDS8283.1

UniProtKB/TrEMBL

K9J9K9

Related

ENSP00000405690.2, ENST00000455756.6

Conserved Domains (4) summary

cd15450
Location:578 → 827

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 497

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:508 → 558

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1131 → 1180

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
NM_001143831.3 → NP_001137303.1 metabotropic glutamate receptor 5 isoform a precursor

See identical proteins and their annotated locations for NP_001137303.1

Status: REVIEWED

Source sequence(s)

AP000626, AP001482, AP001828, AP003120, AP006215

Consensus CDS

CCDS44694.1

UniProtKB/Swiss-Prot

P41594, Q6J164

UniProtKB/TrEMBL

K9J9K9

Related

ENSP00000306138.4, ENST00000305447.5

Conserved Domains (5) summary

cd06374
Location:26 → 497

PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor

pfam00003
Location:591 → 824

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:67 → 472

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:508 → 557

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1162 → 1212

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
NM_001384268.1 → NP_001371197.1 metabotropic glutamate receptor 5 isoform b precursor

Status: REVIEWED

Source sequence(s)

AP000626, AP001482, AP001828, AP003120, AP006215

Consensus CDS

CCDS8283.1

UniProtKB/TrEMBL

K9J9K9

Conserved Domains (4) summary

cd15450
Location:578 → 827

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 497

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:508 → 558

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1131 → 1180

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

88504642..89065982 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011542792.2 → XP_011541094.1 metabotropic glutamate receptor 5 isoform X1

See identical proteins and their annotated locations for XP_011541094.1

UniProtKB/Swiss-Prot

P41594, Q6J164

UniProtKB/TrEMBL

K9J9K9

Conserved Domains (5) summary

cd06374
Location:26 → 497

PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor

pfam00003
Location:591 → 824

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:67 → 472

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:508 → 557

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1162 → 1212

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor