Inpp5d inositol polyphosphate-5-phosphatase D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Inpp5dprovided by MGI
Official Full Name: inositol polyphosphate-5-phosphatase Dprovided by MGI
Primary source: MGI:MGI:107357
See related: Ensembl:ENSMUSG00000026288 AllianceGenome:MGI:107357
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SHIP; SHIP1; SHIP-1; s-SHIP; SIP-145; p150Ship
Summary: Predicted to enable inositol-4,5-bisphosphate 5-phosphatase activity. Acts upstream of or within several processes, including determination of adult lifespan; negative regulation of B cell proliferation; and regulation of hemopoiesis. Predicted to be located in actin filament and cortical cytoskeleton. Predicted to be active in cytosol. Is expressed in several structures, including integumental system; nervous system; respiratory system; skeleton; and spleen. Used to study Paget's disease of bone and systemic lupus erythematosus. Orthologous to human INPP5D (inositol polyphosphate-5-phosphatase D). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 30.1), genital fat pad adult (RPKM 21.2) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 44.44 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (87548034..87648232)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (87620312..87720510)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Inpp5d has disease-relevant and sex-specific effects on glial transcriptomes.
Title: Loss of Inpp5d has disease-relevant and sex-specific effects on glial transcriptomes.
Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy.
Title: Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy.
SHIP1 modulation and proteome characterization of microglia.
Title: SHIP1 modulation and proteome characterization of microglia.
SHIP1 deficiency causes inflammation-dependent retardation in skeletal growth.
Title: SHIP1 deficiency causes inflammation-dependent retardation in skeletal growth.
The Alzheimer's disease risk factor INPP5D restricts neuroprotective microglial responses in amyloid beta-mediated pathology.
Title: The Alzheimer's disease risk factor INPP5D restricts neuroprotective microglial responses in amyloid beta-mediated pathology.
Regulation of Microglial Signaling by Lyn and SHIP-1 in the Steady-State Adult Mouse Brain.
Title: Regulation of Microglial Signaling by Lyn and SHIP-1 in the Steady-State Adult Mouse Brain.
Pathological Roles of INPP5D in Alzheimer's Disease.
Title: Pathological Roles of INPP5D in Alzheimer's Disease.
INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease.
Title: INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease.
Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease.
Title: Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease.
Neuroinflammation after ischemic stroke involves INPP5D expression mediated by the TMPO-AS1-PU.1 complex.
Title: Neuroinflammation after ischemic stroke involves INPP5D expression mediated by the TMPO-AS1-PU.1 complex.

Submit: New GeneRIF Correction See all GeneRIFs (142)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (7) 1 citation
Endonuclease-mediated (5)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Inpp5d (e-PCR), detects polymorphism
- UniSTS:546832

AI323613 (e-PCR)
- UniSTS:178427

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol-4,5-bisphosphate 5-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immunoglobulin mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of bone resorption	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of granulocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of monocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neutrophil differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of neutrophil differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of lymphocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

Names: SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SH2-containing inositol phosphatase SHIP; Src homology 2 domain-containing inositol-5-phosphatase; inositol polyphosphate-5-phosphatase, 145 kDa; phosphatidylinositol-4,5-bisphosphate 5-phosphatase

NP_001103662.1

EC 3.1.3.36

EC 3.1.3.56

EC 3.1.3.86

NP_001103663.1

EC 3.1.3.36

EC 3.1.3.56

EC 3.1.3.86

NP_034696.2

EC 3.1.3.36

EC 3.1.3.56

EC 3.1.3.86

XP_006529212.1

EC 3.1.3.36

EC 3.1.3.56

EC 3.1.3.86

XP_006529213.1

EC 3.1.3.36

EC 3.1.3.56

EC 3.1.3.86

XP_006529214.1

EC 3.1.3.36

EC 3.1.3.56

EC 3.1.3.86

XP_006529217.1

EC 3.1.3.36

EC 3.1.3.56

EC 3.1.3.86

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110192.2 → NP_001103662.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 2

See identical proteins and their annotated locations for NP_001103662.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC102564, AC159967, AK143560, BY197864, U39203

Consensus CDS

CCDS48311.1

UniProtKB/Swiss-Prot

Q9ES52

Related

ENSMUSP00000044647.9, ENSMUST00000042275.15

Conserved Domains (2) summary

cd09100
Location:406 → 712

INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins

cd10343
Location:4 → 105

SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
NM_001110193.2 → NP_001103663.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 3

See identical proteins and their annotated locations for NP_001103663.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains two alternate in-frame exons in the 3' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC102564, AC159967

Consensus CDS

CCDS48310.1

UniProtKB/Swiss-Prot

Q9ES52

Related

ENSMUSP00000131244.2, ENSMUST00000168783.8

Conserved Domains (2) summary

cd09100
Location:407 → 713

INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins

cd10343
Location:4 → 105

SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
NM_010566.3 → NP_034696.2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 1

See identical proteins and their annotated locations for NP_034696.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC159967, AK143560, BY197864

Consensus CDS

CCDS35655.1

UniProtKB/Swiss-Prot

Q3UPF9, Q4U212, Q61034, Q61173, Q61181, Q9ES52, Q9JKR7, Q9JLF9, Q9JLG0, Q9QVN8, Q9WUC2

Related

ENSMUSP00000127941.2, ENSMUST00000169754.8

Conserved Domains (2) summary

cd09100
Location:407 → 713

INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins

cd10343
Location:4 → 105

SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)

RNA

NR_122078.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains two alternate internal exons and uses an alternate splice in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC102564, AC159967

Related

ENSMUST00000072999.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

87548034..87648232

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529149.3 → XP_006529212.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1

Conserved Domains (2) summary

cd09100
Location:407 → 713

INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins

cd10343
Location:4 → 105

SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
XM_006529151.3 → XP_006529214.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X3

Conserved Domains (2) summary

cd09100
Location:407 → 713

INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins

cd10343
Location:4 → 105

SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
XM_006529150.4 → XP_006529213.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X2

Conserved Domains (2) summary

cd09100
Location:406 → 712

INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins

cd10343
Location:4 → 105

SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
XM_006529154.5 → XP_006529217.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X4

Conserved Domains (1) summary

cl00490
Location:43 → 155

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily