Il15 interleukin 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il15provided by MGI
Official Full Name: interleukin 15provided by MGI
Primary source: MGI:MGI:103014
See related: Ensembl:ENSMUSG00000031712 AllianceGenome:MGI:103014
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IL-15
Summary: This gene encodes a a pleiotropic cytokine of the interleukin family of proteins that plays important roles in the innate and adaptive cell homeostasis, as well as peripheral immune function. The encoded protein undergoes proteolytic processing to generate a mature cytokine that stimulates the proliferation of natural killer cells. The transgenic mice overexpressing the encoded protein exhibit an increase in the number of memory CD8+ T cells in a naive state and enhanced protection against bacterial infections. Mice lacking the encoded protein exhibit impaired protection against a strain of attenuated Mycobacterium. [provided by RefSeq, Aug 2016]
Expression: Broad expression in heart adult (RPKM 5.2), duodenum adult (RPKM 3.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C2; 8 39.33 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (83058253..83129883, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (82331624..82403252, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Profibrogenic role of IL-15 through IL-15 receptor alpha-mediated trans-presentation in the carbon tetrachloride-induced liver fibrosis model.
Title: Profibrogenic role of IL-15 through IL-15 receptor alpha-mediated trans-presentation in the carbon tetrachloride-induced liver fibrosis model.
p40 homodimers bridge ischemic tissue inflammation and heterologous alloimmunity in mice via IL-15 transpresentation.
Title: p40 homodimers bridge ischemic tissue inflammation and heterologous alloimmunity in mice via IL-15 transpresentation.
Immunocytokines with target cell-restricted IL-15 activity for treatment of B cell malignancies.
Title: Immunocytokines with target cell-restricted IL-15 activity for treatment of B cell malignancies.
IL-15 Complex-Induced IL-10 Enhances Plasmodium-specific CD4+ T Follicular Helper Differentiation and Antibody Production.
Title: IL-15 Complex-Induced IL-10 Enhances Plasmodium-specific CD4+ T Follicular Helper Differentiation and Antibody Production.
Effects of interleukin-15 on autophagy regulation in the skeletal muscle of mice.
Title: Effects of interleukin-15 on autophagy regulation in the skeletal muscle of mice.
Abnormal M1 polarization of placental macrophage induced by IL-15/STAT5 activation in VVC may lead to adverse pregnancy outcomes.
Title: Abnormal M1 polarization of placental macrophage induced by IL-15/STAT5 activation in VVC may lead to adverse pregnancy outcomes.
Interleukin-15 alters hippocampal synaptic transmission and impairs episodic memory formation in mice.
Title: Interleukin-15 alters hippocampal synaptic transmission and impairs episodic memory formation in mice.
IL-15 Priming Alters IFN-gamma Regulation in Murine NK Cells.
Title: IL-15 Priming Alters IFN-γ Regulation in Murine NK Cells.
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation.
Title: Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation.
MDM2 Inhibition Enhances Immune Checkpoint Inhibitor Efficacy by Increasing IL15 and MHC Class II Production.
Title: MDM2 Inhibition Enhances Immune Checkpoint Inhibitor Efficacy by Increasing IL15 and MHC Class II Production.

Submit: New GeneRIF Correction See all GeneRIFs (288)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (11)
Targeted (8) 1 citation

General gene information

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Markers

Il15 (e-PCR), detects polymorphism
- UniSTS:261906

U14332 (e-PCR)
- UniSTS:159780

D8Mit343 (e-PCR)
- UniSTS:131621

AI503618 (e-PCR)
- UniSTS:179770

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within NK T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell maturation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within extrathymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyaluronan metabolic process	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-15-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-15-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lymph node development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage differentiation	IEA Inferred from Electronic Annotation more info
involved_in macrophage differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of natural killer cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of natural killer cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-17 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of natural killer cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein O-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of defense response to virus by host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001254747.2 → NP_001241676.1 interleukin-15 preproprotein

See identical proteins and their annotated locations for NP_001241676.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC156993

Consensus CDS

CCDS40401.1

UniProtKB/Swiss-Prot

P48346

UniProtKB/TrEMBL

Q3U1Z6

Related

ENSMUSP00000147848.2, ENSMUST00000209363.2

Conserved Domains (1) summary

pfam02372
Location:33 → 154

IL15; Interleukin 15
NM_008357.3 → NP_032383.1 interleukin-15 preproprotein

See identical proteins and their annotated locations for NP_032383.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC156993

Consensus CDS

CCDS40401.1

UniProtKB/Swiss-Prot

P48346

UniProtKB/TrEMBL

Q3U1Z6

Related

ENSMUSP00000034148.7, ENSMUST00000034148.7

Conserved Domains (1) summary

pfam02372
Location:33 → 154

IL15; Interleukin 15