Pou3f2 POU domain, class 3, transcription factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pou3f2provided by MGI
Official Full Name: POU domain, class 3, transcription factor 2provided by MGI
Primary source: MGI:MGI:101895
See related: Ensembl:ENSMUSG00000095139 AllianceGenome:MGI:101895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Brn2; Otf7; Brn-2; OTF-7; oct-7; 9430075J19Rik; A230098E07Rik
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and regulation of gene expression. Acts upstream of or within several processes, including epidermis development; nervous system development; and regulation of axonogenesis. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including future brain; genitourinary system; nervous system; sensory organ; and thymus. Orthologous to human POU3F2 (POU class 3 homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 4 A3; 4 9.73 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (22482095..22488366, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (22482095..22488366, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion.
Title: Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion.
Reduced home cage and social activity in Pou3f2 mice.
Title: Reduced home cage and social activity in Pou3f2⊿ mice.
Data show that a single transcription factor POU domain, class 3, transcription factor 2 protein (Brn2) can convert mouse astrocytes into functional neurons.
Title: Brn2 Alone Is Sufficient to Convert Astrocytes into Neural Progenitors and Neurons.
NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation.
Title: NTF3 Is a Novel Target Gene of the Transcription Factor POU3F2 and Is Required for Neuronal Differentiation.
that POU3F2 is involved in cognitive function as well as adult hippocampal neurogenesis
Title: POU3F2 participates in cognitive function and adult hippocampal neurogenesis via mammalian-characteristic amino acid repeats.
This study investigated changes in the skin in the K5-Brn2 transgenic mouse, which overexpresses Brn2 and contains the keratin 5 promotor. The volume of the eccrine glands was reduced in the K5-Brn2 transgenic mouse.
Title: Effects of Brn2 overexpression on eccrine sweat gland development in the mouse paw.
results suggest that a mutually repressive mechanism exists between Brn1/2 and Rorb expression and that the established expression of Brn1/2 and Rorb further specifies those neurons into L2/3 and L4, respectively, during UCP maturation
Title: Mutually repressive interaction between Brn1/2 and Rorb contributes to the establishment of neocortical layer 2/3 and layer 4.
Mammalian-specific sequences in pou3f2 contribute to maternal behavior.
Title: Mammalian-specific sequences in pou3f2 contribute to maternal behavior.
Brn2-Zic1 axis is essential to specify neural fate in retinoic-acid-treated embryonic stem cells.
Title: A Brn2-Zic1 axis specifies the neuronal fate of retinoic-acid-treated embryonic stem cells.
Brn2 predominantly forms homodimers on MORE cis elements in NS5 mouse neural stem cells
Title: Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:492577 (e-PCR)
- UniSTS:492577

AU048745 (e-PCR)
- UniSTS:145195

Pou3f2 (e-PCR), detects polymorphism
- UniSTS:144243

NoName (e-PCR)
- UniSTS:234878

D4Mit171 (e-PCR), detects polymorphism
- UniSTS:129951

PMC196070P1 (e-PCR)
- UniSTS:271795

PMC317216P1 (e-PCR)
- UniSTS:273079

Pou3f2 (e-PCR), detects polymorphism
- UniSTS:547294

Pou3f2 (e-PCR), detects polymorphism
- UniSTS:536545

BB254306 (e-PCR)
- UniSTS:207603

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables HMG box domain binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Schwann cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cerebral cortex radially oriented cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain astrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain ventricular zone progenitor cell division	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hypothalamus cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myelination in peripheral nervous system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuroendocrine cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurohypophysis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron fate commitment	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron fate specification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: POU domain, class 3, transcription factor 2

Names: brain-2 class III POU-domain protein; brain-specific homeobox/POU domain protein 2; nervous system-specific octamer-binding transcription factor N-Oct-3; octamer-binding protein 7; octamer-binding transcription factor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008899.2 → NP_032925.1 POU domain, class 3, transcription factor 2

See identical proteins and their annotated locations for NP_032925.1

Status: VALIDATED

Source sequence(s)

AL772230

Consensus CDS

CCDS18005.1

UniProtKB/Swiss-Prot

A2AJY1, P31360

Related

ENSMUSP00000136147.2, ENSMUST00000178174.3

Conserved Domains (2) summary

smart00352
Location:264 → 338

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:359 → 413

Homeobox; Homeobox domain