U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    ACKR3 atypical chemokine receptor 3 [ Homo sapiens (human) ]

    Gene ID: 57007, updated on 4-Jan-2025

    Summary

    Official Symbol
    ACKR3provided by HGNC
    Official Full Name
    atypical chemokine receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:23692
    See related
    Ensembl:ENSG00000144476 MIM:610376; AllianceGenome:HGNC:23692
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159
    Summary
    This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 50.1), urinary bladder (RPKM 36.9) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ACKR3 in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (236537122..236582354)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (237027450..237072880)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (237478468..237490997)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene IQ motif containing with AAA domain 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:237300037-237301236 Neighboring gene IQCA1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:237338113-237338612 Neighboring gene ribosomal protein L3 pseudogene 5 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:237348547-237349746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:237458903-237459402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:237459480-237460270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17361 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:237475953-237476828 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:237476829-237477704 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:237488204-237489403 Neighboring gene uncharacterized LOC107986001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:237509317-237509817 Neighboring gene uncharacterized LOC105373946

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C-C chemokine binding  
    enables C-C chemokine receptor activity  
    enables C-X-C chemokine binding PubMed 
    enables C-X-C chemokine receptor activity PubMed 
    enables coreceptor activity  
    enables protein binding PubMed 
    enables scavenger receptor activity PubMed 
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    located_in clathrin-coated pit PubMed 
    located_in early endosome  
    located_in endosome PubMed 
    is_active_in external side of plasma membrane  
    located_in intracellular membrane-bounded organelle  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in recycling endosome  

    General protein information

    Preferred Names
    atypical chemokine receptor 3
    Names
    C-X-C chemokine receptor type 7
    G protein-coupled receptor
    G-protein coupled receptor 159
    G-protein coupled receptor RDC1 homolog
    chemokine (C-X-C motif) receptor 7
    chemokine orphan receptor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020311.3 → NP_064707.1  atypical chemokine receptor 3

      See identical proteins and their annotated locations for NP_064707.1

      Status: REVIEWED

      Source sequence(s)
      BC036661, BP426139, DQ822477
      Consensus CDS
      CCDS2516.1
      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986
      Related
      ENSP00000272928.3, ENST00000272928.4
      Conserved Domains (1) summary
      pfam00001
      Location:62 → 315
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      236537122..236582354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005246098.4 → XP_005246155.1  atypical chemokine receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_005246155.1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986
      Conserved Domains (1) summary
      pfam00001
      Location:62 → 315
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. XM_047445135.1 → XP_047301091.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986
    3. XM_047445136.1 → XP_047301092.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986
    4. XM_005246097.4 → XP_005246154.1  atypical chemokine receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_005246154.1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986
      Conserved Domains (1) summary
      pfam00001
      Location:62 → 315
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      237027450..237072880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343068.1 → XP_054199043.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986
    2. XM_054343064.1 → XP_054199039.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986
    3. XM_054343067.1 → XP_054199042.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986
    4. XM_054343065.1 → XP_054199040.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986
    5. XM_054343063.1 → XP_054199038.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986
    6. XM_054343066.1 → XP_054199041.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986

    Loading
    Loading
    External link. Please review our privacy policy.