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    NEK7 NIMA related kinase 7 [ Homo sapiens (human) ]

    Gene ID: 140609, updated on 27-Nov-2024

    Summary

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    Official Symbol
    NEK7provided by HGNC
    Official Full Name
    NIMA related kinase 7provided by HGNC
    Primary source
    HGNC:HGNC:13386
    See related
    Ensembl:ENSG00000151414 MIM:606848; AllianceGenome:HGNC:13386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]
    Expression
    Ubiquitous expression in heart (RPKM 38.5), fat (RPKM 31.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NEK7 in Genome Data Viewer
    Location:
    1q31.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (198156998..198322420)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (197416379..197581805)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (198126128..198291550)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1664 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1663 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:197887073-197887799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:197890605-197891127 Neighboring gene chromosome 1 open reading frame 53 Neighboring gene LIM homeobox 9 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:198001212-198001386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:198025825-198026449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2280 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2284 Neighboring gene proline rich 13 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 4677 Neighboring gene VISTA enhancer hs1322 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:198283627-198284283 Neighboring gene NANOG hESC enhancer GRCh37_chr1:198392710-198393375 Neighboring gene uncharacterized LOC105371677 Neighboring gene ATPase H+ transporting V1 subunit G3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Activation of Aurora A kinase increases YAP stability via blockage of autophagy. Wang P, et al. Cell Death Dis, 2019 Jun 3. PMID 31160567, Free PMC Article
    2. NEK7 is required for G1 progression and procentriole formation. Gupta A, et al. Mol Biol Cell, 2017 Jul 15. PMID 28539406, Free PMC Article
    3. NEK7 is a centrosomal kinase critical for microtubule nucleation. Kim S, et al. Biochem Biophys Res Commun, 2007 Aug 17. PMID 17586473
    4. Nek7 is overexpressed in hepatocellular carcinoma and promotes hepatocellular carcinoma cell proliferation in vitro and in vivo. Zhou L, et al. Oncotarget, 2016 Apr 5. PMID 26921196, Free PMC Article
    5. Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine. Byrne MJ, et al. Biochem J, 2020 Apr 30. PMID 32242624, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis.
      Title: P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis.
    2. ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
      Title: ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
    3. The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC.
      Title: The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC.
    4. Micro-ribonucleic acid-23a-3p prevents the onset of type 2 diabetes mellitus by suppressing the activation of nucleotide-binding oligomerization-like receptor family pyrin domain containing 3 inflammatory bodies-caused pyroptosis through negatively regulating NIMA-related kinase 7.
      Title: Micro-ribonucleic acid-23a-3p prevents the onset of type 2 diabetes mellitus by suppressing the activation of nucleotide-binding oligomerization-like receptor family pyrin domain containing 3 inflammatory bodies-caused pyroptosis through negatively regulating NIMA-related kinase 7.
    5. Hsa-miR-372-5p regulates the NIMA related kinase 7 and IL-1beta release in NK/T-cell lymphoma.
      Title: Hsa-miR-372-5p regulates the NIMA related kinase 7 and IL-1β release in NK/T-cell lymphoma.
    6. Expression of the NEK7/NLRP3 inflammasome pathway in patients with diabetic lower extremity arterial disease.
      Title: Expression of the NEK7/NLRP3 inflammasome pathway in patients with diabetic lower extremity arterial disease.
    7. EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.
      Title: EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.
    8. Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
      Title: Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
    9. Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.
      Title: Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.
    10. NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-kappaB signaling.
      Title: NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular function activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to potassium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of NLRP3 inflammasome complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spindle assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek7
    Names
    NIMA (never in mitosis gene a)-related kinase 7
    never in mitosis A-related kinase 7
    nimA-related protein kinase 7
    NP_598001.1
    XP_011507511.1
    XP_016855833.1
    XP_016855834.1
    XP_016855835.1
    XP_016855836.1
    XP_047302516.1
    XP_047302517.1
    XP_047302518.1
    XP_047302519.1
    XP_047302520.1
    XP_047302521.1
    XP_047302523.1
    XP_047302524.1
    XP_047302525.1
    XP_047302526.1
    XP_047302528.1
    XP_054190469.1
    XP_054190470.1
    XP_054190471.1
    XP_054190472.1
    XP_054190473.1
    XP_054190474.1
    XP_054190475.1
    XP_054190476.1
    XP_054190477.1
    XP_054190478.1
    XP_054190479.1
    XP_054190480.1
    XP_054190481.1
    XP_054190482.1
    XP_054190483.1
    XP_054190484.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133494.3 → NP_598001.1  serine/threonine-protein kinase Nek7

      See identical proteins and their annotated locations for NP_598001.1

      Status: VALIDATED

      Source sequence(s)
      AC093419, AK313411, DB498485
      Consensus CDS
      CCDS1394.1
      UniProtKB/Swiss-Prot
      A6NGT8, Q8TDX7
      UniProtKB/TrEMBL
      B2R8K8
      Related
      ENSP00000356355.4, ENST00000367385.9
      Conserved Domains (1) summary
      cd08224
      Location:33 → 294
      STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      198156998..198322420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446560.1 → XP_047302516.1  serine/threonine-protein kinase Nek7 isoform X1

    2. XM_047446563.1 → XP_047302519.1  serine/threonine-protein kinase Nek7 isoform X2

      UniProtKB/Swiss-Prot
      A6NGT8, Q8TDX7

    3. XM_047446572.1 → XP_047302528.1  serine/threonine-protein kinase Nek7 isoform X7

    4. XM_017000345.2 → XP_016855834.1  serine/threonine-protein kinase Nek7 isoform X1

      UniProtKB/TrEMBL
      B2R8K8

    5. XM_047446562.1 → XP_047302518.1  serine/threonine-protein kinase Nek7 isoform X2

      UniProtKB/Swiss-Prot
      A6NGT8, Q8TDX7

    6. XM_047446567.1 → XP_047302523.1  serine/threonine-protein kinase Nek7 isoform X4

    7. XM_047446570.1 → XP_047302526.1  serine/threonine-protein kinase Nek7 isoform X7

    8. XM_017000344.2 → XP_016855833.1  serine/threonine-protein kinase Nek7 isoform X1

      UniProtKB/TrEMBL
      B2R8K8

    9. XM_017000346.2 → XP_016855835.1  serine/threonine-protein kinase Nek7 isoform X3

      UniProtKB/TrEMBL
      B2R8K8

    10. XM_047446565.1 → XP_047302521.1  serine/threonine-protein kinase Nek7 isoform X4

    11. XM_011509209.2 → XP_011507511.1  serine/threonine-protein kinase Nek7 isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:9 → 158
      PKc_like; Protein Kinases, catalytic domain

    12. XM_047446569.1 → XP_047302525.1  serine/threonine-protein kinase Nek7 isoform X6

    13. XM_017000347.2 → XP_016855836.1  serine/threonine-protein kinase Nek7 isoform X5

    14. XM_047446568.1 → XP_047302524.1  serine/threonine-protein kinase Nek7 isoform X6

    15. XM_047446561.1 → XP_047302517.1  serine/threonine-protein kinase Nek7 isoform X1

    16. XM_047446564.1 → XP_047302520.1  serine/threonine-protein kinase Nek7 isoform X2

      UniProtKB/Swiss-Prot
      A6NGT8, Q8TDX7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      197416379..197581805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334495.1 → XP_054190470.1  serine/threonine-protein kinase Nek7 isoform X1

    2. XM_054334498.1 → XP_054190473.1  serine/threonine-protein kinase Nek7 isoform X2

      UniProtKB/Swiss-Prot
      A6NGT8, Q8TDX7

    3. XM_054334503.1 → XP_054190478.1  serine/threonine-protein kinase Nek7 isoform X4

    4. XM_054334508.1 → XP_054190483.1  serine/threonine-protein kinase Nek7 isoform X7

    5. XM_054334494.1 → XP_054190469.1  serine/threonine-protein kinase Nek7 isoform X1

    6. XM_054334501.1 → XP_054190476.1  serine/threonine-protein kinase Nek7 isoform X3

    7. XM_054334502.1 → XP_054190477.1  serine/threonine-protein kinase Nek7 isoform X4

    8. XM_054334507.1 → XP_054190482.1  serine/threonine-protein kinase Nek7 isoform X7

    9. XM_054334506.1 → XP_054190481.1  serine/threonine-protein kinase Nek7 isoform X6

    10. XM_054334504.1 → XP_054190479.1  serine/threonine-protein kinase Nek7 isoform X5

    11. XM_054334505.1 → XP_054190480.1  serine/threonine-protein kinase Nek7 isoform X6

    12. XM_054334496.1 → XP_054190471.1  serine/threonine-protein kinase Nek7 isoform X1

    13. XM_054334499.1 → XP_054190474.1  serine/threonine-protein kinase Nek7 isoform X2

      UniProtKB/Swiss-Prot
      A6NGT8, Q8TDX7

    14. XM_054334509.1 → XP_054190484.1  serine/threonine-protein kinase Nek7 isoform X7

    15. XM_054334497.1 → XP_054190472.1  serine/threonine-protein kinase Nek7 isoform X1

    16. XM_054334500.1 → XP_054190475.1  serine/threonine-protein kinase Nek7 isoform X2

      UniProtKB/Swiss-Prot
      A6NGT8, Q8TDX7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TDX7.1 GenPept UniProtKB/Swiss-Prot:Q8TDX7

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